8XIR

Structure of pasireotide-SSTR3 G protein complex

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Somatostatin receptor type 3	polymer	418	45953.3	1	UniProt (P32745) Pfam (PF00001) In PDB	Homo sapiens (human)	SS-3-R,SS3-R,SS3R,SST3,SSR-28
2	B	G-alpha i	polymer	361	41641.2	1		Homo sapiens (human)
3	C	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	377	41055.9	1	UniProt (P62873) Pfam (PF00400) In PDB	Homo sapiens (human)	Transducin beta chain 1
4	D	nanobody Nb35	polymer	156	16926.1	1		Lama glama
5	G	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	1	UniProt (P59768) Pfam (PF00631) In PDB	Homo sapiens (human)	G gamma-I
6	F	Pasireotide	polymer	6	1066.2	1		synthetic construct
7		water	water		18.0	12	Chemie (HOH)

Sequence modifications

A: 1 - 418 (UniProt: P32745)

PDB	External Database	Details
Tyr 262	Val 262	engineered mutation

C: 7 - 345 (UniProt: P62873)

PDB	External Database	Details
Met -5	-	initiating methionine
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
Gly 2	-	expression tag
Ser 3	-	expression tag
Leu 4	-	expression tag
Leu 5	-	expression tag
Gln 6	-	expression tag
Gly 346	-	expression tag
Ser 347	-	expression tag
Ser 348	-	expression tag
Gly 349	-	expression tag
Gly 350	-	expression tag
Gly 351	-	expression tag
Gly 352	-	expression tag
Ser 353	-	expression tag
Gly 354	-	expression tag
Gly 355	-	expression tag
Gly 356	-	expression tag
Gly 357	-	expression tag
Ser 358	-	expression tag
Ser 359	-	expression tag
Gly 360	-	expression tag
Val 361	-	expression tag
Ser 362	-	expression tag
Gly 363	-	expression tag
Trp 364	-	expression tag
Arg 365	-	expression tag
Leu 366	-	expression tag
Phe 367	-	expression tag
Lys 368	-	expression tag
Lys 369	-	expression tag
Ile 370	-	expression tag
Ser 371	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	154503.8
All*	Total formula weight	154503.8

*Water molecules are not included.