8XIP

Structure of Pasireotide-SSTR1 G protein complex

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Somatostatin receptor type 1	polymer	391	42782.0	1	UniProt (P30872) Pfam (PF00001)	Homo sapiens (human)	SS-1-R,SS1-R,SS1R,SST1,SRIF-2
2	B (B)	G-alpha i	polymer	361	41641.2	1		Homo sapiens (human)
3	C (C)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	351	38744.4	1	UniProt (P62873) Pfam (PF25391)	Homo sapiens (human)
4	D (D)	nanobody Nb35	polymer	156	16926.1	1		Lama glama
5	E (G)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	1	UniProt (P59768) Pfam (PF00631)	Homo sapiens (human)	G gamma-I
6	F (E)	004-DTR-LYS-TY5-PHE-A1D5E	polymer	6	1066.2	1		synthetic construct

Sequence modifications

A: 1 - 391 (UniProt: P30872)

PDB	External Database	Details
Tyr 276	Val 276	engineered mutation

C: 7 - 345 (UniProt: P62873)

PDB	External Database	Details
Met -5	-	initiating methionine
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
Gly 2	-	expression tag
Ser 3	-	expression tag
Leu 4	-	expression tag
Leu 5	-	expression tag
Gln 6	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	149021.1
All*	Total formula weight	149021.1

*Water molecules are not included.