8XGJ
Human Cx36/GJD2 gap junction channel in complex with mefloquine.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Gap junction delta-2 protein | polymer | 331 | 37376.9 | 12 | UniProt (Q9UKL4) Pfam (PF00029) | Homo sapiens (human) | Connexin-36,Cx36,Gap junction alpha-9 protein |
| 2 | AB, CA, GC, IB, KA... (F, C, J, G, D...) | (11R,12S)- Mefloquine | non-polymer | 378.3 | 12 | Chemie (YMZ) | |||
| 3 | AA, AC, AD, BA, BB... (B, I, L, F, C...) | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 677.9 | 84 | Chemie (MC3) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L: 1 - 321 (UniProt: Q9UKL4)
| PDB | External Database | Details |
|---|---|---|
| Ser 322 | - | linker |
| Arg 323 | - | linker |
| Asp 324 | - | expression tag |
| Tyr 325 | - | expression tag |
| Lys 326 | - | expression tag |
| Asp 327 | - | expression tag |
| Asp 328 | - | expression tag |
| Asp 329 | - | expression tag |
| Asp 330 | - | expression tag |
| Lys 331 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 448522.9 | |
| Non-Polymers* | Number of molecules | 96 |
| Total formula weight | 61486.1 | |
| All* | Total formula weight | 510009.0 |
