8XFC

Cryo-EM structure of the ATP-bound Mtb DppABCD with the D445A mutation of DppA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Probable dipeptide-transport integral membrane protein ABC transporter DppB	polymer	308	32563.6	1	UniProt (I6YGV9) Pfam (PF19300) Pfam (PF00528)	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
2	B (C)	Probable dipeptide-transport integral membrane protein ABC transporter DppC	polymer	287	30485.7	1	UniProt (L0TEV4) Pfam (PF00528)	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
3	C (D)	Probable dipeptide-transport ATP-binding protein ABC transporter DppD	polymer	548	59018.5	1	UniProt (I6Y482) Pfam (PF00005) Pfam (PF08352)	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
4	D (A)	Probable periplasmic dipeptide-binding lipoprotein DppA	polymer	517	56013.2	1	UniProt (I6X811) Pfam (PF00496)	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
5	E, F (D)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	2	Chemie (ATP)

Sequence modifications

C: 1 - 22 (PDB: 8XFC)
C: 23 - 287 (UniProt: L0TEV4)
D: 1 - 548 (UniProt: I6Y482)

PDB	External Database	Details
Gln 179	Glu 179	engineered mutation
Gln 457	Glu 457	engineered mutation

A: 25 - 541 (UniProt: I6X811)

PDB	External Database	Details
Ala 445	Asp 445	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	178081.1
Non-Polymers*	Number of molecules	2
	Total formula weight	1014.4
All*	Total formula weight	179095.4

*Water molecules are not included.