8XEE

Human DNMT3B mutant-R823G

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	DNA (cytosine-5)-methyltransferase 3B	polymer	284	32420.5	2	UniProt (Q9UBC3) Pfam (PF00145)	Homo sapiens (human)	Dnmt3b,DNA methyltransferase HsaIIIB,DNA MTase HsaIIIB,M.HsaIIIB
2	B, C (B, C)	DNA (cytosine-5)-methyltransferase 3-like	polymer	204	23627.1	2	UniProt (Q9UJW3)	Homo sapiens (human)
3	E, F (A, D)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH)

Sequence modifications

A, D: 571 - 853 (UniProt: Q9UBC3)

PDB	External Database	Details
Met 570	-	initiating methionine
Gly 823	Arg 823	engineered mutation

B, C: 178 - 379 (UniProt: Q9UJW3)

PDB	External Database	Details
Gly 176	-	expression tag
His 177	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	112095.3
Non-Polymers*	Number of molecules	2
	Total formula weight	768.8
All*	Total formula weight	112864.1

*Water molecules are not included.