8XBK
Crystal Structure of Human Liver Fructose-1,6-bisphosphatase Complexed with a Covalent Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Fructose-1,6-bisphosphatase 1 | polymer | 348 | 38206.8 | 4 | UniProt (Q2TU34) Pfam (PF00316) Pfam (PF18913) UniProt (by SIFTS) (P09467) | Homo sapiens (human) | Growth-inhibiting protein 17,cDNA FLJ75786,highly similar to Homo sapiens fructose-1,6-bisphosphatase 1 (FBP1),mRNA |
| 2 | E, M, V, Y (A, B, C, D) | N-[2-[4-[(3-bromophenyl)carbamoylsulfamoyl]phenyl]ethyl]ethanamide | non-polymer | 440.3 | 4 | Chemie (YR9) | |||
| 3 | AA, BA, F, G, H... (D, A, B, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 18 | Chemie (EDO) | |||
| 4 | CA, U, X (D, B, C) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 5 | DA, EA, FA, GA (A, B, C, D) | water | water | 18.0 | 306 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 0 - 337 (UniProt: Q2TU34)
| PDB | External Database | Details |
|---|---|---|
| Leu 338 | - | expression tag |
| Glu 339 | - | expression tag |
| His 340 | - | expression tag |
| His 341 | - | expression tag |
| His 342 | - | expression tag |
| His 343 | - | expression tag |
| His 344 | - | expression tag |
| His 345 | - | expression tag |
| His 346 | - | expression tag |
| His 347 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 152827.4 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 2951.4 | |
| All* | Total formula weight | 155778.8 |
