8XBH

Human GPR34 -Gi complex bound to M1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Guanine nucleotide-binding protein G(i) subunit alpha-1	polymer	354	40415.0	1	UniProt (P63096) Pfam (PF00503) In PDB	Homo sapiens (human)	Adenylate cyclase-inhibiting G alpha protein
2	B	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	344	37799.3	1	UniProt (P54311) Pfam (PF00400) In PDB	Rattus norvegicus (Norway rat)
3	G	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	68	7563.8	1	UniProt (P63212) Pfam (PF00631) In PDB	Bos taurus (cattle)	G gamma-I
4	R	Probable G-protein coupled receptor 34	polymer	396	45702.7	1	UniProt (Q9UPC5) Pfam (PF00001) In PDB	Homo sapiens (human)
5	S	scFv16	polymer	260	27720.8	1		Mus musculus
6	R	(2~{S})-2-azanyl-3-[[(2~{R})-1-ethoxy-3-[3-[2-[(3-phenoxyphenyl)methoxy]phenyl]propanoyloxy]propan-2-yl]oxy-oxidanyl-phosphoryl]oxy-propanoic acid	non-polymer		617.6	1	Chemie (KW3)

Sequence modifications

B: 2 - 340 (UniProt: P54311)

PDB	External Database	Details
Gly -3	-	expression tag
Ser -2	-	expression tag
Gln -1	-	expression tag
Leu 0	-	expression tag
Gln 1	-	expression tag

R: 2 - 381 (UniProt: Q9UPC5)

PDB	External Database	Details
Asp -8	-	expression tag
Tyr -7	-	expression tag
Lys -6	-	expression tag
Asp -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Ala -1	-	expression tag
Met 0	-	expression tag
Gly 1	-	expression tag
Glu 382	-	expression tag
Asn 383	-	expression tag
Leu 384	-	expression tag
Tyr 385	-	expression tag
Phe 386	-	expression tag
Gln 387	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	159201.6
Non-Polymers*	Number of molecules	1
	Total formula weight	617.6
All*	Total formula weight	159819.2

*Water molecules are not included.