8X92
Crystal structure of ROCK2 with GNS-2666 inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Rho-associated protein kinase 2 | polymer | 391 | 45028.2 | 2 | UniProt (O75116) Pfam (PF00069) | Homo sapiens (human) | Rho kinase 2,Rho-associated,coiled-coil-containing protein kinase 2,coiled-coil-containing protein kinase II,ROCK-II,p164 ROCK-2 |
| 2 | C, E (A, B) | ~{N}-methyl-3-[[6-(2-methylpyrazol-3-yl)-1-oxidanylidene-isoquinolin-2-yl]methyl]benzamide | non-polymer | 372.4 | 2 | Chemie (YEW) | |||
| 3 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 80 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 90056.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 840.9 | |
| All* | Total formula weight | 90897.4 |
