8X7R

C05-03-bound E46K alpha-synuclein fibrils

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (F, G, C, D, E...)	Alpha-synuclein	polymer	140	14476.2	10	UniProt (P37840) Pfam (PF01387)	Homo sapiens (human)
2	AA, BA, CA, DA, K... (I, J, F, G, C...)	2-[(~{E})-4-[6-(methylamino)pyridin-3-yl]but-1-en-3-ynyl]-1,3-benzothiazol-6-ol	non-polymer		307.4	20	Chemie (Y9W)

Sequence modifications

F, G, C, D, E, A, B, H, I, J: 1 - 140 (UniProt: P37840)

PDB	External Database	Details
Lys 46	Glu 46	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	144761.8
Non-Polymers*	Number of molecules	20
	Total formula weight	6147.4
All*	Total formula weight	150909.1

*Water molecules are not included.