8X6X

Structure of the multidrug efflux pump EfpA from M. tuberculosis complexed with lipids

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Uncharacterized MFS-type transporter EfpA	polymer	569	59671.4	2	UniProt (P9WJY5) Pfam (PF07690)	Mycobacterium tuberculosis
2	C, E (A, B)	[(2~{R})-1-[(9~{Z},12~{Z},15~{E})-octadeca-9,12,15-trienoyl]oxy-3-phosphonooxy-propan-2-yl] nonadecanoate	non-polymer		713.0	2	Chemie (Y86)
3	D (A)	[(2~{S})-1-dodecanoyloxy-3-phosphonooxy-propan-2-yl] tridecanoate	non-polymer		550.7	1	Chemie (Y8F)

Sequence modifications

A, B: 1 - 530 (UniProt: P9WJY5)

PDB	External Database	Details
Ala 531	-	expression tag
Ala 532	-	expression tag
Ala 533	-	expression tag
Glu 534	-	expression tag
Asn 535	-	expression tag
Leu 536	-	expression tag
Tyr 537	-	expression tag
Phe 538	-	expression tag
Gln 539	-	expression tag
Gly 540	-	expression tag
Leu 541	-	expression tag
Trp 542	-	expression tag
Ser 543	-	expression tag
His 544	-	expression tag
Pro 545	-	expression tag
Gln 546	-	expression tag
Phe 547	-	expression tag
Glu 548	-	expression tag
Lys 549	-	expression tag
Gly 550	-	expression tag
Gly 551	-	expression tag
Gly 552	-	expression tag
Ser 553	-	expression tag
Gly 554	-	expression tag
Gly 555	-	expression tag
Gly 556	-	expression tag
Ser 557	-	expression tag
Gly 558	-	expression tag
Gly 559	-	expression tag
Ser 560	-	expression tag
Ala 561	-	expression tag
Trp 562	-	expression tag
Ser 563	-	expression tag
His 564	-	expression tag
Pro 565	-	expression tag
Gln 566	-	expression tag
Phe 567	-	expression tag
Glu 568	-	expression tag
Lys 569	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	119342.9
Non-Polymers*	Number of molecules	3
	Total formula weight	1976.7
All*	Total formula weight	121319.5

*Water molecules are not included.