8X5X

CryoEM structure of the histamine H1 receptor in apo-form

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B	Histamine H1 receptor,Soluble cytochrome b562	polymer	438	50629.4	1	UniProt (P35367) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361) In PDB	Homo sapiens (human)	H1R,HH1R,Cytochrome b-562

Sequence modifications

B: 19 - 217 (UniProt: P35367)

PDB	External Database	Details
Asp 12	-	expression tag
Tyr 13	-	expression tag
Lys 14	-	expression tag
Asp 15	-	expression tag
Asp 16	-	expression tag
Asp 17	-	expression tag
Asp 18	-	expression tag

B: 306 - 403 (UniProt: P0ABE7)

PDB	External Database	Details
Trp 312	Met 29	conflict
-	Thr 66	deletion
-	Pro 67	deletion
-	Pro 68	deletion
-	Lys 69	deletion
-	Leu 70	deletion
-	Glu 71	deletion
-	Asp 72	deletion
-	Lys 73	deletion
Gly 350	-	insertion
Ser 351	Pro 75	conflict
Gly 352	Asp 76	conflict
Ile 400	His 124	conflict
Leu 404	-	linker
Lys 405	-	linker
Phe 406	-	linker
Cys 407	-	linker

B: 408 - 483 (UniProt: P35367)

PDB	External Database	Details
Lys 218	-	linker
Arg 219	-	linker
Gln 220	-	linker
Leu 221	-	linker
Lys 484	-	expression tag
Ile 485	-	expression tag
Ala 486	-	expression tag
Ala 487	-	expression tag
Leu 488	-	expression tag
Lys 489	-	expression tag
Glu 490	-	expression tag
Lys 491	-	expression tag
Ile 492	-	expression tag
Ala 493	-	expression tag
Ala 494	-	expression tag
Leu 495	-	expression tag
Lys 496	-	expression tag
Glu 497	-	expression tag
Lys 498	-	expression tag
Ile 499	-	expression tag
Ala 500	-	expression tag
Ala 501	-	expression tag
Leu 502	-	expression tag
Lys 503	-	expression tag
Glu 504	-	expression tag
Ala 505	-	expression tag
Glu 506	-	expression tag
Glu 507	-	expression tag
Lys 508	-	expression tag
Arg 509	-	expression tag
Ala 510	-	expression tag
Ser 511	-	expression tag
Arg 512	-	expression tag
Leu 513	-	expression tag
Glu 514	-	expression tag
Glu 515	-	expression tag
Glu 516	-	expression tag
Leu 517	-	expression tag
Arg 518	-	expression tag
Arg 519	-	expression tag
Arg 520	-	expression tag
Leu 521	-	expression tag
Thr 522	-	expression tag
Glu 523	-	expression tag
Gly 524	-	expression tag
Ser 525	-	expression tag
His 526	-	expression tag
His 527	-	expression tag
His 528	-	expression tag
His 529	-	expression tag
His 530	-	expression tag
His 531	-	expression tag
His 532	-	expression tag
His 533	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	50629.4
All*	Total formula weight	50629.4

*Water molecules are not included.