8X4R
Pyruvate kinase M2 (PKM2) mutant in complex with phenylalanine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Pyruvate kinase PKM | polymer | 531 | 57910.8 | 4 | UniProt (P14618) Pfam (PF00224) Pfam (PF02887) | Homo sapiens (human) | |
| 2 | E, G, I, J (A, B, C, D) | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) | |||
| 3 | F, H, K (A, B, D) | PHENYLALANINE | non-polymer | 165.2 | 3 | Chemie (PHE) | |||
| 4 | L, M, N, O (A, B, C, D) | water | water | 18.0 | 527 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 531 (UniProt: P14618)
| PDB | External Database | Details |
|---|---|---|
| Ala 405 | Thr 405 | engineered mutation |
| Ala 406 | Ser 406 | engineered mutation |
| Ala 409 | Thr 409 | engineered mutation |
| Ala 454 | Thr 454 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 231643.2 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 652.0 | |
| All* | Total formula weight | 232295.1 |
