8X3M
Crystal structure of p38alpha with an allosteric inhibitor 2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase 14 | polymer | 365 | 41754.6 | 1 | UniProt (Q16539) Pfam (PF00069) | Homo sapiens (human) | MAP kinase 14,MAPK 14,Cytokine suppressive anti-inflammatory drug-binding protein,CSAID-binding protein,CSBP,MAP kinase MXI2,MAX-interacting protein 2,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha,Stress-activated protein kinase 2a,SAPK2a |
| 2 | B (A) | ~{N}-(5,6-dimethoxy-1,3-benzothiazol-2-yl)-2-[(4-fluoranylphenoxy)methyl]-1,3-thiazole-4-carboxamide | non-polymer | 445.5 | 1 | Chemie (B8Z) | |||
| 3 | C (A) | water | water | 18.0 | 478 | Chemie (HOH) |
Sequence modifications
A: 1 - 360 (UniProt: Q16539)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Leu -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41754.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 445.5 | |
| All* | Total formula weight | 42200.1 |
