8X1X
SARS-CoV-2 Papain like protease (PLpro) in complex with inhibitor Lithocholic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Papain-like protease nsp3 | polymer | 316 | 35786.6 | 1 | UniProt (P0DTD1) Pfam (PF08715) | Severe acute respiratory syndrome coronavirus 2 | Non-structural protein 3,nsp3,PL2-PRO,Papain-like proteinase,PL-PRO |
| 2 | B, C, D (A) | (3beta,5beta,14beta,17alpha)-3-hydroxycholan-24-oic acid | non-polymer | 376.6 | 3 | Chemie (4OA) PubChem (16401214) PubChem (16757763) PubChem (176519949) PubChem (23520755) PubChem (23729583) PubChem (25010533) PubChem (9903) PubChem (177678865) PubChem (44372853) PubChem (44372876) PubChem (44407476) PubChem (94228) PubChem (45044088) PubChem (1770424) PubChem (1770418) PubChem (155410) PubChem (1770422) PubChem (1770420) PubChem (51669129) PubChem (51669131) PubChem (53298680) PubChem (25749306) PubChem (53393619) PubChem (53477689) PubChem (164853) PubChem (40469771) PubChem (40469773) PubChem (57910753) PubChem (57910754) PubChem (58722601) PubChem (376838) PubChem (59032050) PubChem (59283323) PubChem (59725624) PubChem (59877694) PubChem (59899825) PubChem (59963671) PubChem (59997752) PubChem (60115000) PubChem (49796817) PubChem (68361482) PubChem (68846575) PubChem (49838455) PubChem (70226963) PubChem (70834894) PubChem (500165) PubChem (76322297) PubChem (3246738) PubChem (89725691) PubChem (90817030) PubChem (5283803) PubChem (5284070) PubChem (73707448) PubChem (637633) PubChem (89701695) PubChem (5315529) PubChem (5319053) PubChem (90662543) PubChem (92849605) PubChem (117672936) PubChem (121322208) PubChem (6708659) PubChem (6713882) PubChem (7002143) PubChem (92512020) PubChem (125035953) PubChem (126641119) PubChem (71131331) PubChem (95048633) PubChem (6604247) PubChem (133269305) PubChem (7002141) PubChem (7067176) PubChem (7091759) PubChem (7091761) PubChem (9799987) PubChem (124301082) PubChem (124490220) PubChem (11740284) PubChem (11875910) PubChem (11875912) PubChem (11875915) PubChem (145714626) PubChem (12305953) PubChem (12305955) PubChem (12305956) PubChem (14443008) PubChem (124904782) PubChem (124904783) PubChem (124904784) PubChem (124907360) PubChem (124907361) PubChem (153604121) PubChem (125035952) PubChem (125035954) PubChem (125035955) PubChem (162477951) PubChem (162932747) PubChem (126582580) PubChem (126640785) PubChem (126640925) PubChem (126672034) PubChem (126672035) PubChem (129010257) PubChem (134975050) PubChem (139262371) PubChem (139292070) PubChem (142168143) PubChem (142849808) PubChem (143986804) PubChem (144316961) PubChem (145240148) PubChem (145538108) PubChem (155106599) PubChem (155152908) PubChem (155467834) PubChem (155485892) PubChem (155763868) PubChem (144806391) PubChem (162477958) PubChem (162477960) PubChem (162477963) PubChem (162932745) PubChem (162932746) PubChem (162932748) PubChem (163966429) PubChem (169217835) PubChem (171607591) PubChem (145240156) PubChem (173911333) | |||
| 3 | E, F, G (A) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) PubChem (753) | |||
| 4 | H (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) | |||
| 5 | I (A) | water | water | 18.0 | 136 | Chemie (HOH) |
Sequence modifications
A: 1 - 315 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Ser 111 | Cys 1674 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35786.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1429.0 | |
| All* | Total formula weight | 37215.6 |
