8X1U
Cryo-EM structure of human DRA (SLC26A3) bound with oxalate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Chloride anion exchanger | polymer | 775 | 85877.8 | 2 | UniProt (P40879) Pfam (PF00916) Pfam (PF01740) | Homo sapiens (human) | DRA |
| 2 | C, SA (A, B) | OXALATE ION | non-polymer | 88.0 | 2 | Chemie (OXL) | |||
| 3 | D, GC, HC, PA (A, B) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 4 | Chemie (POV) | |||
| 4 | AC, E, I, KA, OB... (B, A) | TETRADECANE | non-polymer | 198.4 | 8 | Chemie (C14) | |||
| 5 | BA, BC, F, FC, HA... (A, B) | DODECANE | non-polymer | 170.3 | 16 | Chemie (D12) | |||
| 6 | AA, DB, EC, FB, G... (A, B) | 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 510.7 | 14 | Chemie (LPE) | |||
| 7 | AB, BB, CA, CB, CC... (B, A) | DECANE | non-polymer | 142.3 | 38 | Chemie (D10) | |||
| 8 | MB, RA (B, A) | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) | |||
| 9 | IC, JC (A, B) | water | water | 18.0 | 18 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 764 (UniProt: P40879)
| PDB | External Database | Details |
|---|---|---|
| Met -10 | - | initiating methionine |
| Asp -9 | - | expression tag |
| Tyr -8 | - | expression tag |
| Lys -7 | - | expression tag |
| Asp -6 | - | expression tag |
| Asp -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Lys -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Thr 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 171755.7 | |
| Non-Polymers* | Number of molecules | 84 |
| Total formula weight | 20858.7 | |
| All* | Total formula weight | 192614.4 |
