8X17
Cryo-EM structure of adenosine receptor A3AR bound to CF102
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37915.5 | 1 | UniProt (P54311) Pfam (PF00400) | Rattus norvegicus (Norway rat) | Transducin beta chain 1 |
| 2 | B (R) | Adenosine receptor A3 | polymer | 318 | 36214.5 | 1 | UniProt (P0DMS8) Pfam (PF00001) | Homo sapiens (human) | |
| 3 | C (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P63212) Pfam (PF00631) | Bos taurus (cattle) | G gamma-I |
| 4 | D (H) | scFv16 | polymer | 247 | 26277.3 | 1 | Mus musculus | ||
| 5 | E (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40445.1 | 1 | UniProt (P63097) Pfam (PF00503) | Bos taurus (cattle) | |
| 6 | F (R) | namodenoson | non-polymer | 544.7 | 1 | Chemie (XS0) |
Sequence modifications
B: 2 - 340 (UniProt: P54311)
A: 1 - 354 (UniProt: P63097)
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | initiating methionine |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 203 | Gly 203 | engineered mutation |
| Ser 326 | Ala 326 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 148713.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 544.7 | |
| All* | Total formula weight | 149258.2 |
