8X0F
Human FL Metabotropic glutamate receptor 5, mGlu5-5M with quisqualate and PAM VU29
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Metabotropic glutamate receptor 5 | polymer | 836 | 93691.5 | 2 | UniProt (P41594) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) | Homo sapiens (human) | |
| 2 | C, F (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 3 | D, G (A, B) | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID | non-polymer | 189.1 | 2 | Chemie (QUS) | |||
| 4 | E (A) | VU29 | non-polymer | 384.4 | 1 | Chemie (XRQ) |
Sequence modifications
A, B: 21 - 856 (UniProt: P41594)
| PDB | External Database | Details |
|---|---|---|
| Leu 350 | His 350 | engineered mutation |
| Ala 445 | Asn 445 | engineered mutation |
| Ala 742 | Thr 742 | engineered mutation |
| Ala 753 | Ser 753 | engineered mutation |
| Ala 777 | Thr 777 | engineered mutation |
| Ala 799 | Ile 799 | engineered mutation |
| Leu 813 | Ala 813 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 187383.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1205.1 | |
| All* | Total formula weight | 188588.0 |
