8X0E
Human FL Metabotropic glutamate receptor 5, mGlu5-5M with agonist and PAM, W785A mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Metabotropic glutamate receptor 5 | polymer | 836 | 93619.4 | 2 | UniProt (P41594) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) | Homo sapiens (human) | |
| 2 | C, E (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 3 | D, F (A, B) | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID | non-polymer | 189.1 | 2 | Chemie (QUS) |
Sequence modifications
A, B: 21 - 856 (UniProt: P41594)
| PDB | External Database | Details |
|---|---|---|
| Leu 350 | His 350 | engineered mutation |
| Ala 742 | Thr 742 | engineered mutation |
| Ala 753 | Ser 753 | engineered mutation |
| Ala 777 | Thr 777 | engineered mutation |
| Ala 785 | Trp 785 | engineered mutation |
| Ala 799 | Ile 799 | engineered mutation |
| Leu 813 | Ala 813 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 187238.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 820.7 | |
| All* | Total formula weight | 188059.4 |
