8WVU
Cryo-EM structure of LGR4 in complex with Rspo1 and RNF43
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Leucine-rich repeat-containing G-protein coupled receptor 4 | polymer | 832 | 91869.5 | 1 | UniProt (Q9BXB1) Pfam (PF01462) Pfam (PF13855) Pfam (PF00001) | Homo sapiens (human) | |
| 2 | B (B) | R-spondin-1 | polymer | 121 | 13313.3 | 1 | UniProt (Q2MKA7) Pfam (PF15913) | Homo sapiens (human) | Roof plate-specific spondin-1,hRspo1 |
| 3 | C (C) | E3 ubiquitin-protein ligase RNF43 | polymer | 166 | 18501.2 | 1 | UniProt (Q68DV7) Pfam (PF18212) | Homo sapiens (human) |
Sequence modifications
A: 24 - 832 (UniProt: Q9BXB1)
B: 35 - 144 (UniProt: Q2MKA7)
C: 44 - 198 (UniProt: Q68DV7)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Lys 2 | - | expression tag |
| Thr 3 | - | expression tag |
| Ile 4 | - | expression tag |
| Ile 5 | - | expression tag |
| Ala 6 | - | expression tag |
| Leu 7 | - | expression tag |
| Ser 8 | - | expression tag |
| Tyr 9 | - | expression tag |
| Ile 10 | - | expression tag |
| Phe 11 | - | expression tag |
| Cys 12 | - | expression tag |
| Leu 13 | - | expression tag |
| Val 14 | - | expression tag |
| Phe 15 | - | expression tag |
| Ala 16 | - | expression tag |
| Asp 17 | - | expression tag |
| Tyr 18 | - | expression tag |
| Lys 19 | - | expression tag |
| Asp 20 | - | expression tag |
| Asp 21 | - | expression tag |
| Asp 22 | - | expression tag |
| Asp 23 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 145 | - | expression tag |
| Ala 146 | - | expression tag |
| Ala 147 | - | expression tag |
| His 148 | - | expression tag |
| His 149 | - | expression tag |
| His 150 | - | expression tag |
| His 151 | - | expression tag |
| His 152 | - | expression tag |
| His 153 | - | expression tag |
| His 154 | - | expression tag |
| His 155 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 199 | - | expression tag |
| Ala 200 | - | expression tag |
| Ala 201 | - | expression tag |
| His 202 | - | expression tag |
| His 203 | - | expression tag |
| His 204 | - | expression tag |
| His 205 | - | expression tag |
| His 206 | - | expression tag |
| His 207 | - | expression tag |
| His 208 | - | expression tag |
| His 209 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 123684.0 | |
| All* | Total formula weight | 123684.0 |
