8WUZ
Development of 2-imino-2,3,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-4(1H)-one derivatives as human caseinolytic peptidase P (hClpP) activators
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | ATP-dependent Clp protease proteolytic subunit, mitochondrial | polymer | 221 | 24179.9 | 7 | UniProt (Q16740) Pfam (PF00574) | Homo sapiens (human) | Endopeptidase Clp |
| 2 | H, J, M, O, Q... (A, B, C, D, E...) | 5-[(3-fluorophenyl)methyl]-9-[[4-(trifluoromethyl)phenyl]methyl]-1,5,9,11-tetrazatricyclo[8.4.0.0^{2,7}]tetradeca-2(7),10-dien-8-one | non-polymer | 472.5 | 7 | Chemie (XFU) PubChem (176170645) | |||
| 3 | I, K, L, N, P... (A, B, C, D, E...) | BROMIDE ION | non-polymer | 79.9 | 8 | Chemie (BR) PubChem (259) |
Sequence modifications
A, B, C, D, E, F, G: 58 - 277 (UniProt: Q16740)
| PDB | External Database | Details |
|---|---|---|
| Ser 57 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 169259.1 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 3946.6 | |
| All* | Total formula weight | 173205.7 |
