8WU1
Cryo-EM structure of CB1-beta-arrestin1 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (C) | Beta-arrestin-1 | polymer | 393 | 44135.3 | 1 | UniProt (P17870) Pfam (PF00339) Pfam (PF02752) | Bos taurus (cattle) | |
| 2 | B (H) | Fab30 heavy chain | polymer | 238 | 25650.5 | 1 | Homo sapiens | ||
| 3 | C (L) | Fab30 light chain | polymer | 215 | 23435.1 | 1 | Homo sapiens | ||
| 4 | D (R) | Cannabinoid receptor 1,Vasopressin V2 receptor | polymer | 443 | 50310.1 | 1 | UniProt (P21554) UniProt (P30518) Pfam (PF00001) | Homo sapiens (human) | |
| 5 | E (R) | methyl N-{1-[(4-fluorophenyl)methyl]-1H-indazole-3-carbonyl}-3-methyl-L-valinate | non-polymer | 397.4 | 1 | Chemie (KCA) |
Sequence modifications
C: 1 - 393 (UniProt: P17870)
R: 1 - 413 (UniProt: P21554)
R: 414 - 443 (UniProt: P30518)
| PDB | External Database | Details |
|---|---|---|
| Glu 169 | Arg 169 | engineered mutation |
| Ala 386 | Ile 386 | engineered mutation |
| Ala 387 | Val 387 | engineered mutation |
| Ala 388 | Phe 388 | engineered mutation |
R: 414 - 443 (UniProt: P30518)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 143531.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 397.4 | |
| All* | Total formula weight | 143928.4 |
