8WTA

Cryo-EM Structure of Human TLR4/MD-2/DLAM3 Complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, B)	Toll-like receptor 4	polymer	605	68838.3	2	UniProt (O00206) Pfam (PF13855) Pfam (PF12799)	Homo sapiens (human)
2	B, D (C, D)	Lymphocyte antigen 96	polymer	142	16385.9	2	UniProt (B3Y6A6) Pfam (PF02221) UniProt (by SIFTS) (Q9Y6Y9)	Homo sapiens (human)
3	E, F, I, J (E, F, I, J)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	4	In PDB GlyTouCan (G15407YE)
4	G, H (G, H)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
5	K, S (A, B)	2-amino-2-deoxy-4-O-phosphono-alpha-D-glucopyranose	non-polymer		259.2	2	Chemie (GP4)
6	L, M, N, T, U... (A, C, B, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)
7	O, R, W, Z (C, D)	(3R)-3-(dodecanoyloxy)tetradecanoic acid	non-polymer		426.7	4	Chemie (2IL)
8	P, X (C, D)	(3R)-3-(tetradecanoyloxy)tetradecanoic acid	non-polymer		454.7	2	Chemie (0IL)
9	Q, Y (C, D)	2-(hydroxymethyl)-5-methoxy-3,6-bis(oxidanyl)pyran-4-one	non-polymer		188.1	2	Chemie (XIQ)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	170448.5
Branched	Number of molecules	6
	Total formula weight	3195.0
Non-Polymers*	Number of molecules	16
	Total formula weight	4838.0
All*	Total formula weight	178481.5

*Water molecules are not included.