8WRO

XBB.1.5.10 spike protein in complex with ACE2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Spike glycoprotein,Spike glycoprotein,Spike glycoprotein,Fusion protein	polymer	1318	145941.6	3	UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) In PDB	Severe acute respiratory syndrome coronavirus 2	S glycoprotein,E2,Peplomer protein
2	D	Processed angiotensin-converting enzyme 2	polymer	594	68804.3	1	UniProt (Q9BYF1) Pfam (PF01401) In PDB	Homo sapiens (human)

Sequence modifications

A, B, C: 1 - 1205 (UniProt: P0DTC2)

PDB	External Database	Details
Ile 19	Thr 19	variant
-	Leu 24	deletion
-	Pro 25	deletion
-	Pro 26	deletion
Ser 24	Ala 27	variant
Ala 80	Val 83	variant
Asp 139	Gly 142	variant
Gln 143	His 146	variant
Glu 180	Gln 183	variant
Glu 210	Val 213	variant
Val 249	Gly 252	variant
His 336	Gly 339	variant
Thr 343	Arg 346	variant
Ile 365	Leu 368	variant
Phe 368	Ser 371	variant
Pro 370	Ser 373	variant
Phe 372	Ser 375	variant
Ala 373	Thr 376	variant
Asn 402	Asp 405	variant
Ser 405	Arg 408	variant
Asn 414	Lys 417	variant
Lys 437	Asn 440	variant
Pro 442	Val 445	variant
Ser 443	Gly 446	variant
Leu 453	Phe 456	variant
Lys 457	Asn 460	variant
Asn 474	Ser 477	variant
Lys 475	Thr 478	variant
Ala 481	Glu 484	variant
Pro 483	Phe 486	conflict
Ser 487	Phe 490	variant
Arg 495	Gln 498	variant
Tyr 498	Asn 501	variant
His 502	Tyr 505	variant
Gly 611	Asp 614	variant
Tyr 652	His 655	variant
Lys 676	Asn 679	variant
His 678	Pro 681	variant
Gly 679	Arg 682	conflict
Ser 680	Arg 683	conflict
Ser 682	Arg 685	conflict
Lys 761	Asn 764	variant
Tyr 793	Asp 796	variant
Pro 814	Phe 817	conflict
Thr 826	Ala 829	conflict
Lys 833	Gln 836	conflict
Pro 889	Ala 892	conflict
Pro 896	Ala 899	conflict
Pro 939	Ala 942	conflict
His 951	Gln 954	variant
Lys 966	Asn 969	variant
Pro 983	Lys 986	variant
Pro 984	Val 987	variant

A, B, C: 1206 - 1318 (PDB: 8WRO)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	506629.2
All*	Total formula weight	506629.2

*Water molecules are not included.