8WR3
Cryo-EM structure of lysosomal protein LYCHOS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Lysosomal cholesterol signaling protein | polymer | 718 | 79323.8 | 2 | UniProt (Q7Z3F1) Pfam (PF03547) | Homo sapiens (human) | LYCHOS |
| 2 | C, H (A, B) | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) | |||
| 3 | D, E, G, I, J... (A, B) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 6 | Chemie (POV) | |||
| 4 | F, K (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
A, B: 1 - 718 (UniProt: Q7Z3F1)
| PDB | External Database | Details |
|---|---|---|
| Leu 653 | Gln 653 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 158647.5 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 5776.2 | |
| All* | Total formula weight | 164423.7 |
