8WPN
Cryo-EM structure of the human TRPC4 in lipid nanodiscs
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Short transient receptor potential channel 4 | polymer | 915 | 105158.0 | 4 | UniProt (Q9UBN4) Pfam (PF12796) Pfam (PF00023) Pfam (PF08344) Pfam (PF00520) | Homo sapiens (human) | TrpC4,Trp-related protein 4,hTrp-4,hTrp4 |
| 2 | E, I, M, R (A, B, C, D) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 4 | Chemie (Y01) | |||
| 3 | F, J, N, S (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | G, K, O, T (A, B, C, D) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 5 | H, L, P, Q (A, B, C, D) | 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE | non-polymer | 648.9 | 4 | Chemie (LPP) |
Sequence modifications
A, B, C, D: 1 - 893 (UniProt: Q9UBN4)
| PDB | External Database | Details |
|---|---|---|
| Ser 894 | - | expression tag |
| Arg 895 | - | expression tag |
| Ala 896 | - | expression tag |
| Ser 897 | - | expression tag |
| Thr 898 | - | expression tag |
| Val 899 | - | expression tag |
| Pro 900 | - | expression tag |
| Arg 901 | - | expression tag |
| Ala 902 | - | expression tag |
| Arg 903 | - | expression tag |
| Asp 904 | - | expression tag |
| Pro 905 | - | expression tag |
| Pro 906 | - | expression tag |
| Val 907 | - | expression tag |
| Ala 908 | - | expression tag |
| Thr 909 | - | expression tag |
| Leu 910 | - | expression tag |
| Glu 911 | - | expression tag |
| Val 912 | - | expression tag |
| Leu 913 | - | expression tag |
| Phe 914 | - | expression tag |
| Gln 915 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 420631.9 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 4964.4 | |
| All* | Total formula weight | 425596.3 |
