8WPN
Cryo-EM structure of the human TRPC4 in lipid nanodiscs
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Short transient receptor potential channel 4 | polymer | 915 | 105158.0 | 4 | UniProt (Q9UBN4) Pfam (PF12796) Pfam (PF00023) Pfam (PF08344) Pfam (PF00520) | Homo sapiens (human) | TrpC4,Trp-related protein 4,hTrp-4,hTrp4 |
| 2 | E, I, M, R (A, B, C, D) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 4 | Chemie (Y01) PubChem (16219150) PubChem (22210610) PubChem (45489984) PubChem (57163942) PubChem (89891013) PubChem (99567468) PubChem (60078761) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (11969853) PubChem (73440805) PubChem (137392566) PubChem (137496323) PubChem (65082) PubChem (363416) PubChem (155804219) PubChem (99567469) PubChem (500055) PubChem (169132514) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (124914595) PubChem (124914596) PubChem (131705526) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (154929912) PubChem (13301926) PubChem (13301927) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) | |||
| 3 | F, J, N, S (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | G, K, O, T (A, B, C, D) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) PubChem (271) | |||
| 5 | H, L, P, Q (A, B, C, D) | 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE | non-polymer | 648.9 | 4 | Chemie (LPP) PubChem (3099) PubChem (446066) PubChem (11061290) |
Sequence modifications
A, B, C, D: 1 - 893 (UniProt: Q9UBN4)
| PDB | External Database | Details |
|---|---|---|
| Ser 894 | - | expression tag |
| Arg 895 | - | expression tag |
| Ala 896 | - | expression tag |
| Ser 897 | - | expression tag |
| Thr 898 | - | expression tag |
| Val 899 | - | expression tag |
| Pro 900 | - | expression tag |
| Arg 901 | - | expression tag |
| Ala 902 | - | expression tag |
| Arg 903 | - | expression tag |
| Asp 904 | - | expression tag |
| Pro 905 | - | expression tag |
| Pro 906 | - | expression tag |
| Val 907 | - | expression tag |
| Ala 908 | - | expression tag |
| Thr 909 | - | expression tag |
| Leu 910 | - | expression tag |
| Glu 911 | - | expression tag |
| Val 912 | - | expression tag |
| Leu 913 | - | expression tag |
| Phe 914 | - | expression tag |
| Gln 915 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 420631.9 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 4964.4 | |
| All* | Total formula weight | 425596.3 |
