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8WPE

Structure of monkeypox virus polymerase complex F8-A22-E4-H5 (tag-free A22) with exogenous DNA

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
DNA polymerasepolymer1006117147.11Pfam (PF08452)
Pfam (PF03104)
Pfam (PF08408)
Pfam (PF00136)
UniProt (by SIFTS) (A0A7H0DN44)
Monkeypox virus
2B
(B)
A22R DNA polymerase processivity factorpolymer42649203.91Pfam (PF05941)
UniProt (by SIFTS) (A0A7H0DNC0)
Monkeypox virus
3C
(C)
E4R Uracil-DNA glycosylase, DNA polymerase processivity factorpolymer21825107.71UniProt (by SIFTS) (M1LL92)Monkeypox virus
4D, E, F, G
(D, E, F, G)
H5R late gene transcription factorpolymer21023107.14Pfam (PF03286)
UniProt (by SIFTS) (A0A7H0DN82)
Monkeypox virusCa2+-binding motif H5R VLTF-4, late transcription factor 4
5H
(H)
Primer DNApolymer3510803.01synthetic construct
6I
(I)
Template DNApolymer4814736.51synthetic construct
7J
(A)
2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATEnon-polymer466.21Chemie (D3T)
8K
(A)
MAGNESIUM IONnon-polymer24.31Chemie (MG)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains9
Total formula weight309426.5
Non-Polymers*Number of molecules2
Total formula weight490.5
All*Total formula weight309917.0
*Water molecules are not included.

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PDB entries from 2025-06-25

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