8WO1

Cryo-EM Structure of Human TLR4/MD-2/DLAM5 Complex

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Toll-like receptor 4	polymer	605	68838.3	2	UniProt (O00206) Pfam (PF13855) Pfam (PF12799) Pfam (PF13516)	Homo sapiens (human)
2	C, D (C, D)	Lymphocyte antigen 96	polymer	142	16385.9	2	UniProt (B3Y6A6) Pfam (PF02221) UniProt (by SIFTS) (Q9Y6Y9)	Homo sapiens (human)
3	E, F, H, I (E, F, H, I)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	4	In PDB GlyTouCan (G15407YE)
4	G, J (G, J)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
5	K, L, N, O, Q... (A, B, C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)
6	M, P (A, B)	2-amino-2-deoxy-4-O-phosphono-alpha-D-glucopyranose	non-polymer		259.2	2	Chemie (GP4)
7	R, W (C, D)	(3R)-3-(dodecanoyloxy)tetradecanoic acid	non-polymer		426.7	2	Chemie (2IL)
8	S, X (C, D)	(3R)-3-(tetradecanoyloxy)tetradecanoic acid	non-polymer		454.7	2	Chemie (0IL)
9	T, Y (C, D)	[(2~{R},3~{S},4~{R},5~{S})-2-(hydroxymethyl)-5-methoxy-4,6-bis(oxidanyl)oxan-3-yl] dihydrogen phosphate	non-polymer		274.2	2	Chemie (X6N)
10	U, Z (C, D)	(3~{S})-3-decanoyloxytetradecanoic acid	non-polymer		398.6	2	Chemie (A1L01)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	170448.5
Branched	Number of molecules	6
	Total formula weight	3195.0
Non-Polymers*	Number of molecules	16
	Total formula weight	4953.9
All*	Total formula weight	178597.4

*Water molecules are not included.