8WGB
mGlu2-4 heterodimer bound with Gi
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (D) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 339 | 37285.7 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 2 | B (E) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 3 | C (B) | Metabotropic glutamate receptor 2 | polymer | 854 | 93861.4 | 1 | UniProt (Q14416) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) | Homo sapiens (human) | |
| 4 | D (C) | Guanine nucleotide-binding protein G(i) subunit alpha-3 | polymer | 354 | 40584.2 | 1 | UniProt (P08754) Pfam (PF00503) | Homo sapiens (human) | |
| 5 | E (R) | Metabotropic glutamate receptor 4 | polymer | 880 | 98365.3 | 1 | UniProt (Q14833) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) | Homo sapiens (human) | |
| 6 | F, G (B, R) | GLUTAMIC ACID | non-polymer | 147.1 | 2 | Chemie (GLU) | |||
| 7 | H (R) | (1R,2S)-2-[[3,5-bis(chloranyl)phenyl]carbamoyl]cyclohexane-1-carboxylic acid | non-polymer | 316.2 | 1 | Chemie (W9R) |
Sequence modifications
C: 1 - 354 (UniProt: P08754)
| PDB | External Database | Details |
|---|---|---|
| Asn 47 | Ser 47 | conflict |
| Ala 203 | Gly 203 | conflict |
| Ala 245 | Glu 245 | conflict |
| Ser 326 | Ala 326 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 277957.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 610.4 | |
| All* | Total formula weight | 278568.2 |
