8WE8
Human L-type voltage-gated calcium channel Cav1.2 in the presence of calciseptine, amlodipine and pinaverium at 2.9 Angstrom resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Voltage-dependent L-type calcium channel subunit alpha-1C | polymer | 2201 | 246851.3 | 1 | UniProt (Q13936) Pfam (PF00520) Pfam (PF16885) Pfam (PF08016) Pfam (PF16905) Pfam (PF08763) | Homo sapiens (human) | Calcium channel,L type,alpha-1 polypeptide,isoform 1,cardiac muscle,Voltage-gated calcium channel subunit alpha Cav1.2 |
| 2 | B (D) | Voltage-dependent calcium channel subunit alpha-2/delta-1 | polymer | 1103 | 124692.5 | 1 | UniProt (P54289) Pfam (PF08399) Pfam (PF00092) Pfam (PF08473) | Homo sapiens (human) | Voltage-gated calcium channel subunit alpha-2/delta-1 |
| 3 | C (C) | Voltage-dependent L-type calcium channel subunit beta-3 | polymer | 484 | 54607.9 | 1 | UniProt (P54284) Pfam (PF12052) Pfam (PF00625) | Homo sapiens (human) | |
| 4 | D (B) | Calciseptin | polymer | 60 | 7056.3 | 1 | UniProt (P22947) Pfam (PF21947) | Dendroaspis polylepis polylepis | |
| 5 | E (E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 627.6 | 1 | In PDB GlyTouCan (G47362BJ) | |||
| 6 | F, H, I (F, H, I) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 7 | G (G) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 830.8 | 1 | In PDB GlyTouCan (G01361SX) | |||
| 8 | J, S (A, D) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 9 | K, L, M, N, V (A, B) | CHOLESTEROL | non-polymer | 386.7 | 5 | Chemie (CLR) | |||
| 10 | O, T, U (A, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 11 | P (A) | [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate | non-polymer | 1047.1 | 1 | Chemie (PT5) | |||
| 12 | Q (A) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 1 | Chemie (3PE) | |||
| 13 | R (A) | amlodipine | non-polymer | 408.9 | 1 | Chemie (6UB) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 433207.8 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2731.6 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 4881.1 | |
| All* | Total formula weight | 440820.5 |
