8WD4
EGFR(L858R/T790/C797S) in complex with compound 5j
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 329 | 37406.3 | 1 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | |
| 2 | B (A) | ~{N}-[3,3-bis(fluoranyl)propyl]-4-[[(2~{S})-butan-2-yl]amino]-6-[[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]amino]pyridine-3-carboxamide | non-polymer | 534.6 | 1 | Chemie (W7W) | |||
| 3 | C (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | D (A) | water | water | 18.0 | 37 | Chemie (HOH) |
Sequence modifications
A: 696 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Ser 694 | - | expression tag |
| Met 695 | - | expression tag |
| Met 790 | Thr 790 | engineered mutation |
| Ser 797 | Cys 797 | engineered mutation |
| Arg 858 | Leu 858 | engineered mutation |
| Ala 865 | Glu 865 | conflict |
| Ala 866 | Glu 866 | conflict |
| Ala 867 | Lys 867 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37406.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 570.0 | |
| All* | Total formula weight | 37976.3 |
