8WAO
Structure of transcribing complex 5 (TC5), the initially transcribing complex with Pol II positioned 5nt downstream of TSS.
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (0) | CDK-activating kinase assembly factor MAT1 | polymer | 309 | 35874.0 | 1 | UniProt (P51948) Pfam (PF17121) Pfam (PF06391) | Homo sapiens (human) | CDK7/cyclin-H assembly factor,Cyclin-G1-interacting protein,Menage a trois,RING finger protein 66,RING finger protein MAT1,p35,p36 |
| 2 | B (1) | General transcription factor IIH subunit 1 | polymer | 548 | 62116.5 | 1 | UniProt (P32780) Pfam (PF08567) Pfam (PF03909) | Homo sapiens (human) | Basic transcription factor 2 62 kDa subunit,BTF2 p62,General transcription factor IIH polypeptide 1,TFIIH basal transcription factor complex p62 subunit |
| 3 | C (2) | General transcription factor IIH subunit 2 | polymer | 395 | 44482.0 | 1 | UniProt (Q13888) Pfam (PF04056) Pfam (PF07975) | Homo sapiens (human) | Basic transcription factor 2 44 kDa subunit,BTF2 p44,General transcription factor IIH polypeptide 2,TFIIH basal transcription factor complex p44 subunit |
| 4 | D (3) | General transcription factor IIH subunit 3 | polymer | 308 | 34416.0 | 1 | UniProt (Q13889) Pfam (PF03850) | Homo sapiens (human) | Basic transcription factor 2 34 kDa subunit,BTF2 p34,General transcription factor IIH polypeptide 3,TFIIH basal transcription factor complex p34 subunit |
| 5 | E (4) | General transcription factor IIH subunit 4 | polymer | 462 | 52245.2 | 1 | UniProt (Q92759) Pfam (PF03849) Pfam (PF18307) | Homo sapiens (human) | Basic transcription factor 2 52 kDa subunit,BTF2 p52,General transcription factor IIH polypeptide 4,TFIIH basal transcription factor complex p52 subunit |
| 6 | F (5) | General transcription factor IIH subunit 5 | polymer | 71 | 8060.4 | 1 | UniProt (Q6ZYL4) Pfam (PF06331) | Homo sapiens (human) | General transcription factor IIH polypeptide 5,TFB5 ortholog,TFIIH basal transcription factor complex TTD-A subunit |
| 7 | G (6) | General transcription and DNA repair factor IIH helicase subunit XPB | polymer | 782 | 89404.7 | 1 | UniProt (P19447) Pfam (PF13625) Pfam (PF04851) Pfam (PF16203) | Homo sapiens (human) | TFIIH subunit XPB,Basic transcription factor 2 89 kDa subunit,BTF2 p89,DNA excision repair protein ERCC-3,DNA repair protein complementing XP-B cells,TFIIH basal transcription factor complex 89 kDa subunit,TFIIH 89 kDa subunit,TFIIH p89,Xeroderma pigmentosum group B-complementing protein |
| 8 | H (7) | General transcription and DNA repair factor IIH helicase subunit XPD | polymer | 760 | 87021.1 | 1 | UniProt (P18074) Pfam (PF06733) Pfam (PF06777) Pfam (PF13307) | Homo sapiens (human) | TFIIH subunit XPD,Basic transcription factor 2 80 kDa subunit,BTF2 p80,CXPD,DNA excision repair protein ERCC-2,DNA repair protein complementing XP-D cells,TFIIH basal transcription factor complex 80 kDa subunit,TFIIH 80 kDa subunit,TFIIH p80,Xeroderma pigmentosum group D-complementing protein |
| 9 | I (N) | Alpha-amanitin | polymer | 8 | 939.0 | 1 | UniProt (P85421) BIRD (PRD_000201) | Amanita phalloides | Amatoxin,Gamma-amanitin |
| 10 | J (Z) | RNA | polymer | 5 | 1788.0 | 1 | synthetic construct | ||
| 11 | K (A) | Transcription initiation factor TFIID subunit 1 | polymer | 1872 | 212956.2 | 1 | UniProt (P21675) Pfam (PF09247) Pfam (PF12157) Pfam (PF15288) Pfam (PF00439) | Homo sapiens (human) | Cell cycle gene 1 protein,TBP-associated factor 250 kDa,p250,Transcription initiation factor TFIID 250 kDa subunit,TAF(II)250,TAFII-250,TAFII250 |
| 12 | L (B) | Transcription initiation factor TFIID subunit 2 | polymer | 1199 | 137160.0 | 1 | UniProt (Q6P1X5) | Homo sapiens (human) | 150 kDa cofactor of initiator function,RNA polymerase II TBP-associated factor subunit B,TBP-associated factor 150 kDa,Transcription initiation factor TFIID 150 kDa subunit,TAF(II)150,TAFII-150,TAFII150 |
| 13 | M, TA (D, d) | Transcription initiation factor TFIID subunit 4 | polymer | 1085 | 110221.9 | 2 | UniProt (O00268) Pfam (PF07531) Pfam (PF05236) | Homo sapiens (human) | RNA polymerase II TBP-associated factor subunit C,TBP-associated factor 4,Transcription initiation factor TFIID 130 kDa subunit,TAF(II)130,TAFII-130,TAFII130,Transcription initiation factor TFIID 135 kDa subunit,TAF(II)135,TAFII-135,TAFII135 |
| 14 | N, UA (E, e) | Transcription initiation factor TFIID subunit 5 | polymer | 800 | 86932.1 | 2 | UniProt (Q15542) Pfam (PF04494) Pfam (PF00400) | Homo sapiens (human) | Transcription initiation factor TFIID 100 kDa subunit,TAF(II)100,TAFII-100,TAFII100 |
| 15 | O, VA (F, f) | Transcription initiation factor TFIID subunit 6 | polymer | 677 | 72749.3 | 2 | UniProt (P49848) Pfam (PF02969) Pfam (PF07571) | Homo sapiens (human) | RNA polymerase II TBP-associated factor subunit E,Transcription initiation factor TFIID 70 kDa subunit,TAF(II)70,TAFII-70,TAFII70,Transcription initiation factor TFIID 80 kDa subunit,TAF(II)80,TAFII-80,TAFII80 |
| 16 | P (G) | Transcription initiation factor TFIID subunit 7 | polymer | 349 | 40325.1 | 1 | UniProt (Q15545) Pfam (PF04658) | Homo sapiens (human) | RNA polymerase II TBP-associated factor subunit F,Transcription initiation factor TFIID 55 kDa subunit,TAF(II)55,TAFII-55,TAFII55 |
| 17 | Q (H) | Transcription initiation factor TFIID subunit 8 | polymer | 310 | 34304.4 | 1 | UniProt (Q7Z7C8) Pfam (PF07524) Pfam (PF10406) | Homo sapiens (human) | Protein taube nuss,TBP-associated factor 43 kDa,TBP-associated factor 8,Transcription initiation factor TFIID 43 kDa subunit,TAFII-43,TAFII43,hTAFII43 |
| 18 | R, WA (I, i) | Transcription initiation factor TFIID subunit 9 | polymer | 264 | 29006.8 | 2 | UniProt (Q16594) Pfam (PF02291) | Homo sapiens (human) | RNA polymerase II TBP-associated factor subunit G,STAF31/32,Transcription initiation factor TFIID 31 kDa subunit,TAFII-31,TAFII31,Transcription initiation factor TFIID 32 kDa subunit,TAFII-32,TAFII32 |
| 19 | S, XA (J, j) | Transcription initiation factor TFIID subunit 10 | polymer | 218 | 21731.2 | 2 | UniProt (Q12962) Pfam (PF03540) | Homo sapiens (human) | STAF28,Transcription initiation factor TFIID 30 kDa subunit,TAF(II)30,TAFII-30,TAFII30 |
| 20 | T, YA (L, l) | Transcription initiation factor TFIID subunit 12 | polymer | 161 | 17948.5 | 2 | UniProt (Q16514) Pfam (PF03847) | Homo sapiens (human) | Transcription initiation factor TFIID 20/15 kDa subunits,TAFII-20/TAFII-15,TAFII20/TAFII15 |
| 21 | U (O) | Transcription initiation factor IIA subunit 2 | polymer | 109 | 12469.1 | 1 | UniProt (P52657) Pfam (PF02268) Pfam (PF02751) | Homo sapiens (human) | General transcription factor IIA subunit 2,TFIIA p12 subunit,TFIIA-12,TFIIAS,Transcription initiation factor IIA gamma chain,TFIIA-gamma |
| 22 | V (P) | TATA-box-binding protein | polymer | 339 | 37729.9 | 1 | UniProt (P20226) Pfam (PF00352) | Homo sapiens (human) | TATA sequence-binding protein,TATA-binding factor,TATA-box factor,Transcription initiation factor TFIID TBP subunit |
| 23 | W (Q) | Transcription initiation factor IIA beta chain | polymer | 376 | 41544.6 | 1 | UniProt (P52655) Pfam (PF03153) | Homo sapiens (human) | TFIIA p19 subunit |
| 24 | X (R) | Transcription initiation factor IIB | polymer | 316 | 34877.9 | 1 | UniProt (Q00403) Pfam (PF08271) Pfam (PF00382) | Homo sapiens (human) | General transcription factor TFIIB,S300-II |
| 25 | Y (S) | General transcription factor IIF subunit 1 | polymer | 517 | 58343.6 | 1 | UniProt (P35269) Pfam (PF05793) | Homo sapiens (human) | General transcription factor IIF 74 kDa subunit,Transcription initiation factor IIF subunit alpha,TFIIF-alpha,Transcription initiation factor RAP74 |
| 26 | Z (T) | General transcription factor IIF subunit 2 | polymer | 249 | 28427.3 | 1 | UniProt (P13984) Pfam (PF17683) Pfam (PF02270) | Homo sapiens (human) | ATP-dependent helicase GTF2F2,General transcription factor IIF 30 kDa subunit,Transcription initiation factor IIF subunit beta,TFIIF-beta,Transcription initiation factor RAP30 |
| 27 | AA (U) | General transcription factor IIE subunit 1 | polymer | 439 | 49516.1 | 1 | UniProt (P29083) Pfam (PF02002) Pfam (PF08271) Pfam (PF11521) | Homo sapiens (human) | General transcription factor IIE 56 kDa subunit,Transcription initiation factor IIE subunit alpha,TFIIE-alpha |
| 28 | BA (V) | Transcription initiation factor IIE subunit beta | polymer | 291 | 33106.8 | 1 | UniProt (P29084) Pfam (PF02186) Pfam (PF18121) | Homo sapiens (human) | TFIIE-beta,General transcription factor IIE subunit 2 |
| 29 | CA (X) | non-template DNA | polymer | 99 | 30617.6 | 1 | synthetic construct | ||
| 30 | DA (Y) | template DNA | polymer | 99 | 30466.5 | 1 | synthetic construct | ||
| 31 | EA (c) | Transcription initiation factor TFIID subunit 3 | polymer | 929 | 103769.3 | 1 | UniProt (Q5VWG9) Pfam (PF07524) Pfam (PF00628) | Homo sapiens (human) | 140 kDa TATA box-binding protein-associated factor,TBP-associated factor 3,Transcription initiation factor TFIID 140 kDa subunit,TAF(II)140,TAF140,TAFII-140,TAFII140 |
| 32 | FA (k) | Transcription initiation factor TFIID subunit 11 | polymer | 211 | 23340.1 | 1 | UniProt (Q15544) Pfam (PF04719) | Homo sapiens (human) | TFIID subunit p30-beta,Transcription initiation factor TFIID 28 kDa subunit,TAF(II)28,TAFII-28,TAFII28 |
| 33 | GA (m) | Transcription initiation factor TFIID subunit 13 | polymer | 124 | 14307.1 | 1 | UniProt (Q15543) Pfam (PF02269) | Homo sapiens (human) | Transcription initiation factor TFIID 18 kDa subunit,TAF(II)18,TAFII-18,TAFII18 |
| 34 | HA (o) | DNA-directed RNA polymerase subunit | polymer | 1970 | 217420.0 | 1 | UniProt (A0A8D1DPV6) Pfam (PF05001) Pfam (PF04997) Pfam (PF00623) Pfam (PF04983) Pfam (PF05000) Pfam (PF04998) Pfam (PF04992) Pfam (PF04990) | Sus scrofa (pig) | |
| 35 | IA (p) | DNA-directed RNA polymerase subunit beta | polymer | 1174 | 134041.4 | 1 | UniProt (A0A4X1TVZ5) Pfam (PF04563) Pfam (PF04561) Pfam (PF04565) Pfam (PF04566) Pfam (PF04567) Pfam (PF00562) Pfam (PF04560) | Sus scrofa (pig) | |
| 36 | JA (q) | DNA-directed RNA polymerase II subunit RPB3 | polymer | 275 | 31439.1 | 1 | UniProt (I3LCH3) Pfam (PF01193) Pfam (PF01000) | Sus scrofa (pig) | RNA polymerase II subunit C |
| 37 | KA (r) | DNA-directed RNA polymerase II subunit RPB4 | polymer | 142 | 16331.3 | 1 | UniProt (A0A481BYI6) Pfam (PF03874) | Sus scrofa (pig) | DNA-directed RNA polymerase II subunit RPB4 isoform X1 |
| 38 | LA (s) | DNA-directed RNA polymerase II subunit E | polymer | 210 | 24644.3 | 1 | UniProt (A0A4X1VTX4) Pfam (PF03871) Pfam (PF01191) | Sus scrofa (pig) | RPB5 homolog |
| 39 | MA (t) | DNA-directed RNA polymerase II subunit F | polymer | 127 | 14477.0 | 1 | UniProt (A0A4X1VEK9) Pfam (PF01192) | Sus scrofa (pig) | DNA-directed RNA polymerases I,II,and III subunit RPABC2,RPB6 homolog |
| 40 | NA (u) | DNA-directed RNA polymerase II subunit RPB7 | polymer | 172 | 19314.3 | 1 | UniProt (A0A4X1VKG7) Pfam (PF03876) Pfam (PF00575) | Sus scrofa (pig) | |
| 41 | OA (v) | DNA-directed RNA polymerases I, II, and III subunit RPABC3 | polymer | 150 | 17162.3 | 1 | UniProt (I3LCB2) Pfam (PF03870) | Sus scrofa (pig) | |
| 42 | PA (w) | DNA-directed RNA polymerase II subunit RPB9 | polymer | 125 | 14541.2 | 1 | UniProt (P60899) Pfam (PF02150) Pfam (PF01096) | Sus scrofa (pig) | RNA polymerase II subunit B9,DNA-directed RNA polymerase II subunit I,RNA polymerase II 14.5 kDa subunit,RPB14.5 |
| 43 | QA (x) | DNA-directed RNA polymerases I, II, and III subunit RPABC5 | polymer | 67 | 7655.1 | 1 | UniProt (A0A493TD97) Pfam (PF01194) | Sus scrofa (pig) | |
| 44 | RA (y) | DNA-directed RNA polymerase II subunit RPB11-a | polymer | 117 | 13310.3 | 1 | UniProt (F1RKE4) Pfam (PF13656) | Sus scrofa (pig) | |
| 45 | SA (z) | RPB12 | polymer | 58 | 7018.2 | 1 | UniProt (A0A4X1TRS6) Pfam (PF03604) | Sus scrofa (pig) | |
| 46 | AB, BB, CB, DB, EB... (0, 2, 3, R, U...) | ZINC ION | non-polymer | 65.4 | 17 | Chemie (ZN) | |||
| 47 | GB (7) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 1 | Chemie (SF4) | |||
| 48 | LB (o) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 49 | MB (p) | [[(2~{S},3~{R},4~{S},5~{R})-5-(2-azanyl-6-oxidanylidene-3~{H}-purin-9-yl)-3-methoxy-4-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | non-polymer | 537.2 | 1 | Chemie (W0F) |
Sequence modifications
o: 1 - 1970 (UniProt: A0A8D1DPV6)
| PDB | External Database | Details |
|---|---|---|
| Ala 1835 | Thr 1835 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 51 |
| Total formula weight | 2534142.5 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 2025.1 | |
| All* | Total formula weight | 2536167.6 |
