8W89
Cryo-EM structure of the PEA-bound TAAR1-Gs complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 246 | 28302.9 | 1 | Pfam (PF00503) UniProt (by SIFTS) (P04899) UniProt (by SIFTS) (P63092) | Homo sapiens (human) | |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37915.5 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (N) | Nanobody35 | polymer | 139 | 15271.9 | 1 | Lama glama | ||
| 5 | E (R) | Trace amine-associated receptor 1 | polymer | 339 | 39130.6 | 1 | UniProt (Q96RJ0) Pfam (PF00001) | Homo sapiens (human) | TaR-1,Trace amine receptor 1 |
| 6 | F (R) | 2-PHENYLETHYLAMINE | non-polymer | 122.2 | 1 | Chemie (PEA) | |||
| 7 | G (R) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | initiating methionine |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 128482.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 122.2 | |
| All* | Total formula weight | 128604.3 |
