8W5Z
Crystal structure of tick tyrosylprotein sulfotransferase reveals the activation mechanism of tick anticoagulant protein madanin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Protein-tyrosine sulfotransferase (Fragment) | polymer | 393 | 44801.2 | 2 | UniProt (A0A147BHN3) Pfam (PF13469) UniProt (by SIFTS) (B7Q097) | Ixodes | |
| 2 | B, D (B, D) | Madanin Y54-peptide | polymer | 11 | 1320.2 | 2 | longicornis species complex | ||
| 3 | E, P (A, C) | ADENOSINE-3'-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (A3P) | |||
| 4 | F, G, J, K (A) | 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE | non-polymer | 201.2 | 4 | Chemie (1PS) | |||
| 5 | H, I, L, M (A) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 4 | Chemie (TRS) | |||
| 6 | N, O, Q, R (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 7 | S, T, U, V (A, B, C, D) | water | water | 18.0 | 484 | Chemie (HOH) |
Sequence modifications
A, C: 48 - 393 (UniProt: A0A147BHN3)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Arg 2 | - | expression tag |
| Gly 3 | - | expression tag |
| Met 4 | - | expression tag |
| Val 5 | - | expression tag |
| Ala 6 | - | expression tag |
| His 7 | - | expression tag |
| Arg 8 | - | expression tag |
| Leu 9 | - | expression tag |
| Thr 10 | - | expression tag |
| Arg 11 | - | expression tag |
| Arg 12 | - | expression tag |
| Trp 13 | - | expression tag |
| Phe 14 | - | expression tag |
| Leu 15 | - | expression tag |
| Leu 16 | - | expression tag |
| Ser 17 | - | expression tag |
| Ala 18 | - | expression tag |
| Leu 19 | - | expression tag |
| Ser 20 | - | expression tag |
| Leu 21 | - | expression tag |
| Phe 22 | - | expression tag |
| Gly 23 | - | expression tag |
| Leu 24 | - | expression tag |
| Val 25 | - | expression tag |
| Leu 26 | - | expression tag |
| Leu 27 | - | expression tag |
| Tyr 28 | - | expression tag |
| Ser 29 | - | expression tag |
| Leu 30 | - | expression tag |
| Leu 31 | - | expression tag |
| Gly 32 | - | expression tag |
| Ser 33 | - | expression tag |
| Cys 34 | - | expression tag |
| Arg 35 | - | expression tag |
| Gln 36 | - | expression tag |
| Arg 37 | - | expression tag |
| Ala 38 | - | expression tag |
| Ser 39 | - | expression tag |
| Asn 40 | - | expression tag |
| Phe 41 | - | expression tag |
| Thr 42 | - | expression tag |
| Tyr 43 | - | expression tag |
| Val 44 | - | expression tag |
| Ser 45 | - | expression tag |
| Pro 46 | - | expression tag |
| Asp 47 | - | expression tag |
| Ala 374 | Ser 327 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 92242.8 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 2245.2 | |
| All* | Total formula weight | 94488.0 |
