8W4L
Crystal structure of closed conformation of human immunoglobulin Fc in presence of EndoSz
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Immunoglobulin gamma-1 heavy chain | polymer | 223 | 25129.5 | 2 | UniProt (P0DOX5) Pfam (PF07654) | Homo sapiens (human) | |
| 2 | C (C) | N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1916.7 | 1 | In PDB GlyTouCan (G23295TF) | |||
| 3 | D (D) | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1787.6 | 1 | In PDB GlyTouCan (G78059CC) | |||
| 4 | E, F (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) |
Sequence modifications
A, B: 225 - 447 (UniProt: P0DOX5)
| PDB | External Database | Details |
|---|---|---|
| Glu 356 | Asp 358 | variant |
| Met 358 | Leu 360 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 50259.0 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 3704.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 70.9 | |
| All* | Total formula weight | 54034.3 |
