8W4F
SARS-CoV-2 spike protein in complex with a trivalent nanobody
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Spike glycoprotein | polymer | 1120 | 123893.2 | 3 | UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) | Severe acute respiratory syndrome coronavirus 2 | S glycoprotein,E2,Peplomer protein |
| 2 | D, E, F (D, E, F) | Tribody | polymer | 197 | 20878.4 | 3 | synthetic construct |
Sequence modifications
A, B, C: 27 - 1146 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| Ala 683 | Arg 683 | engineered mutation |
| Ala 685 | Arg 685 | engineered mutation |
| Pro 817 | Phe 817 | engineered mutation |
| Pro 892 | Ala 892 | engineered mutation |
| Pro 899 | Ala 899 | engineered mutation |
| Pro 942 | Ala 942 | engineered mutation |
| Pro 986 | Lys 986 | engineered mutation |
| Pro 987 | Val 987 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 434314.9 | |
| All* | Total formula weight | 434314.9 |
