8W46
X-ray crystal structure of V30M-TTR in complex with pterostilbene
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Transthyretin | polymer | 159 | 17342.6 | 2 | UniProt (P02766) Pfam (PF00576) | Homo sapiens (human) | ATTR,Prealbumin,TBPA |
| 2 | C, E, F (A, B) | Pterostilbene | non-polymer | 256.3 | 3 | Chemie (3RL) | |||
| 3 | D (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 182 | Chemie (HOH) |
Sequence modifications
A, B: -19 - 127 (UniProt: P02766)
| PDB | External Database | Details |
|---|---|---|
| Met -31 | - | initiating methionine |
| Arg -30 | - | expression tag |
| Gly -29 | - | expression tag |
| Ser -28 | - | expression tag |
| His -27 | - | expression tag |
| His -26 | - | expression tag |
| His -25 | - | expression tag |
| His -24 | - | expression tag |
| His -23 | - | expression tag |
| His -22 | - | expression tag |
| Gly -21 | - | expression tag |
| Ser -20 | - | expression tag |
| Met 30 | Val 50 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 34685.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 791.9 | |
| All* | Total formula weight | 35477.0 |
