8W2X

TAS-120 covalent structure with FGFR2

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Fibroblast growth factor receptor 2	polymer	324	37126.7	2	UniProt (P21802) Pfam (PF07714)	Homo sapiens (human)	FGFR-2,K-sam,KGFR,Keratinocyte growth factor receptor
2	C, H (A, B)	1-[(3S)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]propan-1-one	non-polymer		420.5	2	Chemie (A1AFR)
3	D (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	E, F, G, I (A, B)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
5	J, K (A, B)	water	water		18.0	28	Chemie (HOH)

Sequence modifications

A, B: 458 - 768 (UniProt: P21802)

PDB	External Database	Details
Met 445	-	initiating methionine
Gly 446	-	expression tag
Ser 447	-	expression tag
Ser 448	-	expression tag
His 449	-	expression tag
His 450	-	expression tag
His 451	-	expression tag
His 452	-	expression tag
His 453	-	expression tag
His 454	-	expression tag
Ser 455	-	expression tag
Gln 456	-	expression tag
Asp 457	-	expression tag
Val 650	Asp 650	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	74253.4
Non-Polymers*	Number of molecules	7
	Total formula weight	1317.3
All*	Total formula weight	75570.7

*Water molecules are not included.