8W28
Cryo-EM structure of human tankyrase 2 SAM-PARP filament bound to compound, XAV (focused refinement map).
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (D, Q) | Maltose/maltodextrin-binding periplasmic protein,Poly [ADP-ribose] polymerase tankyrase-2 | polymer | 729 | 80614.0 | 2 | UniProt (P0AEY0) UniProt (Q9H2K2) Pfam (PF07647) Pfam (PF00644) | Homo sapiens (human) | MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,Protein poly-ADP-ribosyltransferase tankyrase-2,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-2,TANK2,Tankyrase-like protein,Tankyrase-related protein |
| 2 | C, E (D, Q) | 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol | non-polymer | 312.3 | 2 | Chemie (XAV) | |||
| 3 | D, F (D, Q) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | G, H (D, Q) | water | water | 18.0 | 40 | Chemie (HOH) |
Sequence modifications
D, Q: 474 - 838 (UniProt: P0AEY0)
D, Q: 850 - 1166 (UniProt: Q9H2K2)
| PDB | External Database | Details |
|---|---|---|
| Met 438 | - | initiating methionine |
| Ser 439 | - | expression tag |
| Ala 440 | - | expression tag |
| Trp 441 | - | expression tag |
| Ser 442 | - | expression tag |
| His 443 | - | expression tag |
| Pro 444 | - | expression tag |
| Gln 445 | - | expression tag |
| Phe 446 | - | expression tag |
| Glu 447 | - | expression tag |
| Lys 448 | - | expression tag |
| Gly 449 | - | expression tag |
| Gly 450 | - | expression tag |
| Gly 451 | - | expression tag |
| Ser 452 | - | expression tag |
| Gly 453 | - | expression tag |
| Gly 454 | - | expression tag |
| Gly 455 | - | expression tag |
| Ser 456 | - | expression tag |
| Gly 457 | - | expression tag |
| Gly 458 | - | expression tag |
| Ser 459 | - | expression tag |
| Ala 460 | - | expression tag |
| Trp 461 | - | expression tag |
| Ser 462 | - | expression tag |
| His 463 | - | expression tag |
| Pro 464 | - | expression tag |
| Gln 465 | - | expression tag |
| Phe 466 | - | expression tag |
| Glu 467 | - | expression tag |
| Lys 468 | - | expression tag |
| Thr 469 | - | expression tag |
| Gly 470 | - | expression tag |
| Ser 471 | - | expression tag |
| Met 472 | - | expression tag |
| Gly 473 | - | expression tag |
| Glu 839 | - | linker |
| Leu 840 | - | linker |
| Glu 841 | - | linker |
| Leu 842 | - | linker |
| Glu 843 | - | linker |
| Val 844 | - | linker |
| Leu 845 | - | linker |
| Phe 846 | - | linker |
| Gln 847 | - | linker |
| Gly 848 | - | linker |
| Pro 849 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 161228.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 755.4 | |
| All* | Total formula weight | 161983.5 |
