8W27

Cryo-EM structure of human tankyrase 2 SAM-PARP filament bound to compound, XAV (consensus map).

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Maltose/maltodextrin-binding periplasmic protein,Poly [ADP-ribose] polymerase tankyrase-2	polymer	729	80614.0	20	UniProt (P0AEY0) UniProt (Q9H2K2) Pfam (PF07647) Pfam (PF00644)	Homo sapiens (human)	MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,Protein poly-ADP-ribosyltransferase tankyrase-2,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-2,TANK2,Tankyrase-like protein,Tankyrase-related protein
2	AA, AB, CA, CB, EA... (D, R, E, S, F...)	2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol	non-polymer		312.3	20	Chemie (XAV)
3	BA, BB, DA, DB, FA... (D, R, E, S, F...)	ZINC ION	non-polymer		65.4	20	Chemie (ZN)

Sequence modifications

A, B, C, D, E, F, G, H, I, J, L, M, N, O, P, Q, R, S, T, U: 474 - 838 (UniProt: P0AEY0)

PDB	External Database	Details
Met 438	-	initiating methionine
Ser 439	-	expression tag
Ala 440	-	expression tag
Trp 441	-	expression tag
Ser 442	-	expression tag
His 443	-	expression tag
Pro 444	-	expression tag
Gln 445	-	expression tag
Phe 446	-	expression tag
Glu 447	-	expression tag
Lys 448	-	expression tag
Gly 449	-	expression tag
Gly 450	-	expression tag
Gly 451	-	expression tag
Ser 452	-	expression tag
Gly 453	-	expression tag
Gly 454	-	expression tag
Gly 455	-	expression tag
Ser 456	-	expression tag
Gly 457	-	expression tag
Gly 458	-	expression tag
Ser 459	-	expression tag
Ala 460	-	expression tag
Trp 461	-	expression tag
Ser 462	-	expression tag
His 463	-	expression tag
Pro 464	-	expression tag
Gln 465	-	expression tag
Phe 466	-	expression tag
Glu 467	-	expression tag
Lys 468	-	expression tag
Thr 469	-	expression tag
Gly 470	-	expression tag
Ser 471	-	expression tag
Met 472	-	expression tag
Gly 473	-	expression tag
Glu 839	-	linker
Leu 840	-	linker
Glu 841	-	linker
Leu 842	-	linker
Glu 843	-	linker
Val 844	-	linker
Leu 845	-	linker
Phe 846	-	linker
Gln 847	-	linker
Gly 848	-	linker
Pro 849	-	linker

A, B, C, D, E, F, G, H, I, J, L, M, N, O, P, Q, R, S, T, U: 850 - 1166 (UniProt: Q9H2K2)

Contents of the asymmetric unit

Polymers	Number of chains	20
	Total formula weight	1612280.2
Non-Polymers*	Number of molecules	40
	Total formula weight	7554.4
All*	Total formula weight	1619834.5

*Water molecules are not included.