8W0G

Cryo-EM structure of a human MCM2-7 dimer

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, G (2, A)	DNA replication licensing factor MCM2	polymer	904	102034.1	2	UniProt (P49736) Pfam (PF12619) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855)	Homo sapiens (human)	Minichromosome maintenance protein 2 homolog,Nuclear protein BM28
2	B, H (3, B)	DNA replication licensing factor MCM3	polymer	810	91251.9	2	UniProt (P25205) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855)	Homo sapiens (human)	DNA polymerase alpha holoenzyme-associated protein P1,P1-MCM3,RLF subunit beta,p102
3	C, I (4, C)	DNA replication licensing factor MCM4	polymer	866	96975.1	2	UniProt (P33991) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855)	Homo sapiens (human)	CDC21 homolog,P1-CDC21
4	D, J (5, D)	DNA replication licensing factor MCM5	polymer	734	82406.6	2	UniProt (P33992) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) Pfam (PF21933)	Homo sapiens (human)	CDC46 homolog,P1-CDC46
5	E, K (6, E)	DNA replication licensing factor MCM6	polymer	821	93010.3	2	UniProt (Q14566) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) Pfam (PF18263)	Homo sapiens (human)	p105MCM
6	F, L (7, F)	DNA replication licensing factor MCM7	polymer	719	81411.9	2	UniProt (P33993) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855)	Homo sapiens (human)	CDC47 homolog,P1.1-MCM3
7	BA, GA, JA, KA, M... (A, C, D, E, 2...)	ZINC ION	non-polymer		65.4	10	Chemie (ZN)
8	CA, EA, HA, LA, N... (A, B, C, E, 2...)	MAGNESIUM ION	non-polymer		24.3	10	Chemie (MG)
9	AA, DA, IA, MA, O... (7, A, C, E, 2...)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	8	Chemie (ATP)
10	FA, Q (B, 3)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	2	Chemie (ADP)

Sequence modifications

3, B: 2 - 808 (UniProt: P25205)

PDB	External Database	Details
Ser -1	-	expression tag
Asn 0	-	expression tag
Ala 1	-	expression tag

4, C: 1 - 863 (UniProt: P33991)

PDB	External Database	Details
Ser -2	-	expression tag
Asn -1	-	expression tag
Ala 0	-	expression tag
Met 650	Leu 650	variant

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	1094179.9
Non-Polymers*	Number of molecules	30
	Total formula weight	5809.0
All*	Total formula weight	1099988.9

*Water molecules are not included.