8W0F
Cryo-EM structure of a human MCM2-7 double hexamer on dsDNA
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, G (2, A) | DNA replication licensing factor MCM2 | polymer | 904 | 102034.1 | 2 | UniProt (P49736) Pfam (PF12619) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) | Homo sapiens (human) | Minichromosome maintenance protein 2 homolog,Nuclear protein BM28 |
| 2 | B, H (3, B) | DNA replication licensing factor MCM3 | polymer | 810 | 91251.9 | 2 | UniProt (P25205) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) | Homo sapiens (human) | DNA polymerase alpha holoenzyme-associated protein P1,P1-MCM3,RLF subunit beta,p102 |
| 3 | C, I (4, C) | DNA replication licensing factor MCM4 | polymer | 866 | 96975.1 | 2 | UniProt (P33991) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) | Homo sapiens (human) | CDC21 homolog,P1-CDC21 |
| 4 | D, J (5, D) | DNA replication licensing factor MCM5 | polymer | 734 | 82406.6 | 2 | UniProt (P33992) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) Pfam (PF21933) | Homo sapiens (human) | CDC46 homolog,P1-CDC46 |
| 5 | E, K (6, E) | DNA replication licensing factor MCM6 | polymer | 821 | 93010.3 | 2 | UniProt (Q14566) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) Pfam (PF18263) | Homo sapiens (human) | p105MCM |
| 6 | F, L (7, F) | DNA replication licensing factor MCM7 | polymer | 719 | 81411.9 | 2 | UniProt (P33993) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) | Homo sapiens (human) | CDC47 homolog,P1.1-MCM3 |
| 7 | M (O) | DNA (47-MER) | polymer | 47 | 14459.4 | 1 | Saccharomyces cerevisiae | ||
| 8 | N (S) | DNA (47-MER) | polymer | 47 | 14468.4 | 1 | Saccharomyces cerevisiae | ||
| 9 | AA, DA, IA, JA, MA... (7, A, C, D, E...) | ZINC ION | non-polymer | 65.4 | 10 | Chemie (ZN) | |||
| 10 | BA, EA, GA, KA, NA... (7, A, B, D, E...) | MAGNESIUM ION | non-polymer | 24.3 | 10 | Chemie (MG) | |||
| 11 | FA, Q (A, 2) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 12 | CA, HA, LA, OA, RA... (7, B, D, E, F...) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 8 | Chemie (ADP) |
Sequence modifications
3, B: 2 - 808 (UniProt: P25205)
4, C: 1 - 863 (UniProt: P33991)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Asn 0 | - | expression tag |
| Ala 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Met 650 | Leu 650 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 14 |
| Total formula weight | 1123107.7 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 5329.1 | |
| All* | Total formula weight | 1128436.9 |
