8W0E
Cryo-EM structure of a human MCM2-7 single hexamer on dsDNA
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (2) | DNA replication licensing factor MCM2 | polymer | 904 | 102034.1 | 1 | UniProt (P49736) Pfam (PF12619) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) | Homo sapiens (human) | Minichromosome maintenance protein 2 homolog,Nuclear protein BM28 |
| 2 | B (3) | DNA replication licensing factor MCM3 | polymer | 810 | 91251.9 | 1 | UniProt (P25205) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) | Homo sapiens (human) | DNA polymerase alpha holoenzyme-associated protein P1,P1-MCM3,RLF subunit beta,p102 |
| 3 | C (4) | DNA replication licensing factor MCM4 | polymer | 866 | 96975.1 | 1 | UniProt (P33991) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) | Homo sapiens (human) | CDC21 homolog,P1-CDC21 |
| 4 | D (5) | DNA replication licensing factor MCM5 | polymer | 734 | 82406.6 | 1 | UniProt (P33992) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) Pfam (PF21933) | Homo sapiens (human) | CDC46 homolog,P1-CDC46 |
| 5 | E (6) | DNA replication licensing factor MCM6 | polymer | 821 | 93010.3 | 1 | UniProt (Q14566) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) Pfam (PF18263) | Homo sapiens (human) | p105MCM |
| 6 | F (7) | DNA replication licensing factor MCM7 | polymer | 719 | 81411.9 | 1 | UniProt (P33993) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) | Homo sapiens (human) | CDC47 homolog,P1.1-MCM3 |
| 7 | G (O) | DNA (25-MER) | polymer | 25 | 7785.2 | 1 | Saccharomyces cerevisiae | ||
| 8 | H (S) | DNA (25-MER) | polymer | 25 | 7559.9 | 1 | Saccharomyces cerevisiae | ||
| 9 | I, N, O, R, U (2, 4, 5, 6, 7) | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) | |||
| 10 | J, L, P, S, V (2, 3, 5, 6, 7) | MAGNESIUM ION | non-polymer | 24.3 | 5 | Chemie (MG) | |||
| 11 | K (2) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 12 | M, Q, T, W (3, 5, 6, 7) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 4 | Chemie (ADP) |
Sequence modifications
3: 2 - 808 (UniProt: P25205)
4: 1 - 863 (UniProt: P33991)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Asn 0 | - | expression tag |
| Ala 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Met 650 | Leu 650 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 562435.0 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 2664.6 | |
| All* | Total formula weight | 565099.6 |
