8VZQ
Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with k-406
This is a non-PDB format compatible entry.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Estrogen receptor | polymer | 242 | 27561.4 | 4 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
2 | A, B, C, D | (1S,2R,4S)-N-(2-fluoro-2-methylpropyl)-5,6-bis(4-hydroxyphenyl)-N-(4-methoxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide | non-polymer | 539.6 | 4 | Chemie (A1AHX) | |||
3 | A, C | NICKEL (II) ION | non-polymer | 58.7 | 2 | Chemie (NI) | |||
4 | water | water | 18.0 | 427 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 305 - 546 (UniProt: P03372)
PDB | External Database | Details |
---|---|---|
Ser 372 | Leu 372 | engineered mutation |
Ser 536 | Leu 536 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 110245.5 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 2275.8 | |
All* | Total formula weight | 112521.4 |