8VYT
Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with k-411
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Estrogen receptor | polymer | 243 | 27699.5 | 4 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | A, B, C, D | 4,4'-[(1R,4R,5S)-5-(2,3-dihydro-1H-indole-1-sulfonyl)-7-oxabicyclo[2.2.1]hept-2-ene-2,3-diyl]diphenol | non-polymer | 461.5 | 4 | Chemie (A1AHV) | |||
| 3 | water | water | 18.0 | 606 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 305 - 547 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 372 | Leu 372 | engineered mutation |
| Ser 536 | Leu 536 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 110798.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1846.1 | |
| All* | Total formula weight | 112644.2 |
