8VYP
Cryo-EM Structure of the BRAF V600E monomer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 14-3-3 protein zeta/delta | polymer | 245 | 27777.1 | 2 | UniProt (P63104) Pfam (PF00244) | Homo sapiens (human) | Protein kinase C inhibitor protein 1,KCIP-1 |
| 2 | C (C) | Serine/threonine-protein kinase B-raf | polymer | 767 | 84784.7 | 1 | UniProt (P15056) Pfam (PF02196) Pfam (PF00130) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1 |
| 3 | D (C) | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | non-polymer | 523.2 | 1 | Chemie (AGS) |
Sequence modifications
C: 1 - 766 (UniProt: P15056)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Glu 600 | Val 600 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 140338.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 523.2 | |
| All* | Total formula weight | 140862.2 |
