8VX8

Cryo-EM Structure of DHX36 bound to the cMyc DNA G-quadruplex, Class 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	ATP-dependent DNA/RNA helicase DHX36	polymer	972	111646.9	1	UniProt (Q05B79) Pfam (PF00270) Pfam (PF00271) Pfam (PF04408) Pfam (PF21010) Pfam (PF07717)	Bos taurus (cattle)	DEAD/H box polypeptide 36,DEAH-box protein 36,G4-resolvase-1,G4R1,MLE-like protein 1,RNA helicase associated with AU-rich element protein
2	B, C (B, C)	DNA (29-MER)	polymer	29	9119.8	2		synthetic construct

Sequence modifications

A: 48 - 1010 (UniProt: Q05B79)

PDB	External Database	Details
Ala 147	Glu 147	engineered mutation
Ala 148	Lys 148	engineered mutation
Ala 149	Lys 149	engineered mutation
Pro 1011	-	expression tag
His 1012	-	expression tag
His 1013	-	expression tag
His 1014	-	expression tag
His 1015	-	expression tag
His 1016	-	expression tag
His 1017	-	expression tag
His 1018	-	expression tag
His 1019	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	129886.6
All*	Total formula weight	129886.6

*Water molecules are not included.