8VX6

Human OGG1 bound at the nucleosomal DNA entry site

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (J)	DNA (167-MER)	polymer	167	51343.7	1		synthetic construct
2	B (I)	DNA (167-MER)	polymer	167	51786.0	1		synthetic construct
3	C, G (A, E)	Histone H3.2	polymer	136	15435.1	2	UniProt (P84233) Pfam (PF00125)	Xenopus laevis (African clawed frog)	Histone H3
4	D, H (B, F)	Histone H4	polymer	120	13307.5	2	UniProt (P62799) Pfam (PF15511)	Xenopus laevis (African clawed frog)
5	E, I (C, G)	Histone H2A	polymer	165	18087.0	2	UniProt (Q6AZJ8) Pfam (PF00125) Pfam (PF16211) UniProt (by SIFTS) (P06897)	Xenopus laevis (African clawed frog)
6	F, J (D, H)	Histone H2B 1.1	polymer	123	13655.9	2	UniProt (P02281) Pfam (PF00125)	Xenopus laevis (African clawed frog)	H2B1.1
7	K (K)	N-glycosylase/DNA lyase	polymer	387	43720.0	1	UniProt (O15527) Pfam (PF07934) Pfam (PF00730)	Homo sapiens (human)

Sequence modifications

A, E: 0 - 135 (UniProt: P84233)

PDB	External Database	Details
Ala 102	Gly 103	engineered mutation

B, F: 0 - 102 (UniProt: P62799)

PDB	External Database	Details
Ser 103	-	expression tag
Ser 104	-	expression tag
Gly 105	-	expression tag
Leu 106	-	expression tag
Val 107	-	expression tag
Pro 108	-	expression tag
Arg 109	-	expression tag
Gly 110	-	expression tag
Ser 111	-	expression tag
Leu 112	-	expression tag
Glu 113	-	expression tag
His 114	-	expression tag
His 115	-	expression tag
His 116	-	expression tag
His 117	-	expression tag
His 118	-	expression tag
His 119	-	expression tag

C, G: 0 - 129 (UniProt: Q6AZJ8)

PDB	External Database	Details
Met -35	-	expression tag
Lys -34	-	expression tag
Glu -33	-	expression tag
Thr -32	-	expression tag
Ala -31	-	expression tag
Ala -30	-	expression tag
Ala -29	-	expression tag
Lys -28	-	expression tag
Phe -27	-	expression tag
Glu -26	-	expression tag
Arg -25	-	expression tag
Gln -24	-	expression tag
His -23	-	expression tag
Met -22	-	expression tag
Asp -21	-	expression tag
Ser -20	-	expression tag
Pro -19	-	expression tag
Asp -18	-	expression tag
Leu -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Gly -10	-	expression tag
Thr -9	-	expression tag
Leu -8	-	expression tag
Val -7	-	expression tag
Pro -6	-	expression tag
Arg -5	-	expression tag
Gly -4	-	expression tag
Ser -3	-	expression tag
Met -2	-	expression tag
Gly -1	-	expression tag

D, H: 1 - 122 (UniProt: P02281)

PDB	External Database	Details
Met 0	-	initiating methionine
Thr 29	Ser 33	engineered mutation

K: 2 - 345 (UniProt: O15527)

PDB	External Database	Details
Met -41	-	expression tag
Gly -40	-	expression tag
His -39	-	expression tag
His -38	-	expression tag
His -37	-	expression tag
His -36	-	expression tag
His -35	-	expression tag
His -34	-	expression tag
Asp -33	-	expression tag
Tyr -32	-	expression tag
Lys -31	-	expression tag
Asp -30	-	expression tag
His -29	-	expression tag
Asp -28	-	expression tag
Gly -27	-	expression tag
Asp -26	-	expression tag
Tyr -25	-	expression tag
Lys -24	-	expression tag
Asp -23	-	expression tag
His -22	-	expression tag
Asp -21	-	expression tag
Ile -20	-	expression tag
Asp -19	-	expression tag
Tyr -18	-	expression tag
Lys -17	-	expression tag
Asp -16	-	expression tag
Asp -15	-	expression tag
Asp -14	-	expression tag
Asp -13	-	expression tag
Lys -12	-	expression tag
Glu -11	-	expression tag
Asn -10	-	expression tag
Leu -9	-	expression tag
Tyr -8	-	expression tag
Phe -7	-	expression tag
Gln -6	-	expression tag
Gly -5	-	expression tag
Gly -4	-	expression tag
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Asp 1	-	expression tag
Gln 249	Lys 249	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	11
	Total formula weight	267820.7
All*	Total formula weight	267820.7

*Water molecules are not included.