8VX0
CRYSTAL STRUCTURE OF CYP2C9*14 IN COMPLEX WITH LOSARTAN
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cytochrome P450 2C9 | polymer | 473 | 53802.3 | 1 | UniProt (P11712) Pfam (PF00067) | Homo sapiens (human) | (R)-limonene 6-monooxygenase,(S)-limonene 6-monooxygenase,(S)-limonene 7-monooxygenase,CYPIIC9,Cholesterol 25-hydroxylase,Cytochrome P-450MP,Cytochrome P450 MP-4,Cytochrome P450 MP-8,Cytochrome P450 PB-1,S-mephenytoin 4-hydroxylase |
| 2 | B, C (A) | [2-butyl-5-chloranyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol | non-polymer | 422.9 | 2 | Chemie (LSN) | |||
| 3 | D (A) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 4 | E (A) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
| 5 | F (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 6 | G (A) | water | water | 18.0 | 103 | Chemie (HOH) |
Sequence modifications
A: 24 - 490 (UniProt: P11712)
| PDB | External Database | Details |
|---|---|---|
| Met 19 | - | initiating methionine |
| Ala 20 | - | insertion |
| Lys 21 | - | insertion |
| Lys 22 | - | insertion |
| Thr 23 | - | insertion |
| His 125 | Arg 125 | engineered mutation |
| Ile 490 | Val 490 | engineered mutation |
| His 491 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 53802.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1596.4 | |
| All* | Total formula weight | 55398.7 |
