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8VW4

Crystal structure of Cbl-b TKB bound to compound 26

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BE3 ubiquitin-protein ligase CBL-Bpolymer31036191.62UniProt (Q13191)
Pfam (PF02262)
Pfam (PF02761)
Pfam (PF02762)
In PDB
Homo sapiens (human)Casitas B-lineage lymphoma proto-oncogene b,RING finger protein 56,RING-type E3 ubiquitin transferase CBL-B,SH3-binding protein CBL-B,Signal transduction protein CBL-B
2A, BMAGNESIUM IONnon-polymer24.32Chemie (MG)
3A, B(7-methoxy-2-{2-[(1S,3S,4S)-3-(3-methoxy-2-methyl-5-nitrophenyl)-1-methyl-5-oxo-1,5-dihydroimidazo[1,5-a]pyridin-2(3H)-yl]-2-oxoethoxy}quinolin-8-yl)acetic acidnon-polymer588.62Chemie (A1AEG)
4AGLYCEROLnon-polymer92.13Chemie (GOL)
5BDI(HYDROXYETHYL)ETHERnon-polymer106.11Chemie (PEG)
6waterwater18.0171Chemie (HOH)
Sequence modifications
A, B: 36 - 343 (UniProt: Q13191)
PDBExternal DatabaseDetails
Gly 34-expression tag
Ser 35-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight72383.1
Non-Polymers*Number of molecules8
Total formula weight1608.1
All*Total formula weight73991.2
*Water molecules are not included.

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PDB entries from 2024-07-24

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