Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8VVV

Mammalian ribosomes bound to Anisomycin in the nonrotated conformation

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	uL2	polymer	257	28088.9	1	UniProt (G1TT27) Pfam (PF00181) Pfam (PF03947)	Oryctolagus cuniculus (rabbit)
2	B (B)	uL3	polymer	403	46108.0	1	UniProt (G1TL06) Pfam (PF00297)	Oryctolagus cuniculus (rabbit)
3	C (C)	uL4	polymer	413	46401.9	1	UniProt (G1SVW5) Pfam (PF00573) Pfam (PF14374)	Oryctolagus cuniculus (rabbit)	60S ribosomal protein L4
4	D (D)	uL18	polymer	297	34481.8	1	UniProt (G1SYJ6) UniProt (by SIFTS) (P19949)	Oryctolagus cuniculus (rabbit)
5	E (E)	L6	polymer	291	33028.3	1	UniProt (G1SKF7) Pfam (PF03868) Pfam (PF01159)	Oryctolagus cuniculus (rabbit)
6	F (F)	uL30	polymer	249	29514.3	1	UniProt (G1SV32) Pfam (PF08079) Pfam (PF00327)	Oryctolagus cuniculus (rabbit)
7	G (G)	eL8	polymer	319	36221.5	1	UniProt (G1STW0) Pfam (PF01248)	Oryctolagus cuniculus (rabbit)
8	H (H)	uL6	polymer	192	21871.4	1	UniProt (G1SWI6) Pfam (PF00347)	Oryctolagus cuniculus (rabbit)
9	I (I)	L10	polymer	214	24643.1	1	UniProt (B7NZQ2) Pfam (PF00252)	Oryctolagus cuniculus (rabbit)
10	J (J)	uL5	polymer	178	20288.5	1	UniProt (G1TUB8) Pfam (PF00281) Pfam (PF00673)	Oryctolagus cuniculus (rabbit)
11	K (L)	eL13	polymer	211	24331.7	1	UniProt (G1TPV0)	Oryctolagus cuniculus (rabbit)
12	L (M)	eL14	polymer	218	23870.5	1	UniProt (G1SZ12) Pfam (PF01929)	Oryctolagus cuniculus (rabbit)
13	M (N)	eL15	polymer	204	24207.3	1	UniProt (G1T0C1) Pfam (PF00827)	Oryctolagus cuniculus (rabbit)
14	N (O)	uL13	polymer	203	23533.3	1		Oryctolagus cuniculus (rabbit)
15	O (P)	uL22	polymer	213	24938.4	1	UniProt (G1TVT6) Pfam (PF00237) UniProt (by SIFTS) (G1SCJ6)	Oryctolagus cuniculus (rabbit)	60S ribosomal protein L17
16	P (Q)	eL18	polymer	188	21699.7	1	UniProt (G1TFE0) Pfam (PF17135)	Oryctolagus cuniculus (rabbit)
17	Q (R)	eL19	polymer	212	25455.5	1		Oryctolagus cuniculus (rabbit)
18	R (S)	eL20	polymer	224	26103.4	1		Oryctolagus cuniculus (rabbit)
19	S (T)	eL21	polymer	160	18610.0	1	UniProt (G1SHQ2) Pfam (PF01157)	Oryctolagus cuniculus (rabbit)
20	T (U)	eL22	polymer	128	14813.0	1	UniProt (G1TSG1) Pfam (PF01776)	Oryctolagus cuniculus (rabbit)
21	U (V)	L23	polymer	140	14892.5	1	UniProt (G1T6D1) Pfam (PF00238)	Oryctolagus cuniculus (rabbit)
22	V (W)	uL24	polymer	157	17765.0	1	UniProt (G1SE28) Pfam (PF01246)	Oryctolagus cuniculus (rabbit)	60S ribosomal protein L24
23	W (X)	uL23	polymer	156	17768.2	1	UniProt (G1SE76) Pfam (PF03939) Pfam (PF00276)	Oryctolagus cuniculus (rabbit)
24	X (Y)	L26	polymer	145	17303.4	1	UniProt (G1SQH0) Pfam (PF16906) Pfam (PF00467)	Oryctolagus cuniculus (rabbit)
25	Y (Z)	L27	polymer	136	15835.8	1	UniProt (G1TXF6) Pfam (PF00467) Pfam (PF01777)	Oryctolagus cuniculus (rabbit)
26	Z (AA)	uS2	polymer	295	32958.0	1	UniProt (G1TLT8) Pfam (PF00318) Pfam (PF16122)	Oryctolagus cuniculus (rabbit)	40S ribosomal protein SA, 37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40
27	AA (BB)	S3A	polymer	264	30002.1	1	UniProt (G1SS70) Pfam (PF01015)	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S3a
28	BA (CC)	eS1	polymer	293	31327.4	1		Oryctolagus cuniculus (rabbit)
29	CA (5)	28S rRNA	polymer	3635	1179574.9	1		Oryctolagus cuniculus (rabbit)
30	DA (7)	5S rRNA	polymer	120	38691.9	1	GenBank (X06789.1)	Oryctolagus cuniculus (rabbit)
31	EA (8)	5.8S rRNA	polymer	156	50157.7	1		Oryctolagus cuniculus (rabbit)
32	FA (a)	uL15	polymer	147	16489.4	1	UniProt (G1SNY0) Pfam (PF00828)	Oryctolagus cuniculus (rabbit)
33	GA (b)	eL29	polymer	245	26708.7	1	UniProt (G1SGR6) Pfam (PF01779)	Oryctolagus cuniculus (rabbit)
34	HA (c)	eL30	polymer	98	10914.8	1	UniProt (G1TDL2) Pfam (PF01248)	Oryctolagus cuniculus (rabbit)
35	IA (d)	eL31	polymer	107	12635.7	1	UniProt (G1SHG0) Pfam (PF01198)	Oryctolagus cuniculus (rabbit)
36	JA (e)	eL32	polymer	128	15022.0	1	UniProt (G1U437) Pfam (PF01655) UniProt (by SIFTS) (G1TUN8)	Oryctolagus cuniculus (rabbit)
37	KA (f)	eL33	polymer	109	12449.6	1	UniProt (G1SF08) Pfam (PF01247)	Oryctolagus cuniculus (rabbit)
38	LA (g)	eL34	polymer	114	12994.6	1	UniProt (G1TXG5) Pfam (PF01199)	Oryctolagus cuniculus (rabbit)
39	MA (h)	uL29	polymer	122	14435.4	1	UniProt (G1SIT5) Pfam (PF00831)	Oryctolagus cuniculus (rabbit)
40	NA (i)	eL36	polymer	102	11888.4	1	UniProt (G1TTQ5) Pfam (PF01158)	Oryctolagus cuniculus (rabbit)
41	OA (j)	eL37	polymer	86	10090.9	1	UniProt (U3KPD5) Pfam (PF01907)	Oryctolagus cuniculus (rabbit)
42	PA (k)	eL38	polymer	69	8107.8	1		Oryctolagus cuniculus (rabbit)
43	QA (l)	eL39	polymer	50	6324.6	1	UniProt (G1TTN1) Pfam (PF00832)	Oryctolagus cuniculus (rabbit)
44	RA (m)	eL40	polymer	52	6212.6	1		Oryctolagus cuniculus (rabbit)
45	SA (n)	eL41	polymer	25	3473.5	1	UniProt (A0A087WNH4) Pfam (PF05162)	Oryctolagus cuniculus (rabbit)	60s ribosomal protein l41
46	TA (o)	eL42	polymer	103	12070.5	1	UniProt (G1T040) Pfam (PF00935)	Oryctolagus cuniculus (rabbit)
47	UA (p)	eL43	polymer	91	10168.2	1	UniProt (G1SY53) Pfam (PF01780)	Oryctolagus cuniculus (rabbit)
48	VA (r)	eL28	polymer	124	14220.7	1	UniProt (G1U7L1) Pfam (PF01778)	Oryctolagus cuniculus (rabbit)
49	WA (s)	uL10	polymer	196	21521.1	1	UniProt (G1SPK4) Pfam (PF00466) Pfam (PF17777)	Oryctolagus cuniculus (rabbit)
50	XA (t)	eL11	polymer	153	16561.1	1	UniProt (G1SMR7) Pfam (PF03946) Pfam (PF00298)	Oryctolagus cuniculus (rabbit)
51	YA (v)	eukaryotic elongation factor 2	polymer	839	93391.0	1		Oryctolagus cuniculus (rabbit)
52	ZA (w)	Serpine mRNA binding protein 1	polymer	26	3083.3	1		Oryctolagus cuniculus (rabbit)
53	AB (9)	18S rRNA	polymer	1698	548239.4	1		Oryctolagus cuniculus (rabbit)
54	BB (DD)	uS3	polymer	228	25215.6	1	UniProt (G1TNM3) Pfam (PF07650) Pfam (PF00189)	Oryctolagus cuniculus (rabbit)
55	CB (EE)	eS4	polymer	262	29523.7	1	UniProt (G1TA47) Pfam (PF08071) Pfam (PF00900) Pfam (PF00467) Pfam (PF16121)	Oryctolagus cuniculus (rabbit)
56	DB (FF)	uS7	polymer	204	22913.5	1	UniProt (G1TFM5) Pfam (PF00177)	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S5
57	EB (GG)	eS6	polymer	237	27471.5	1	UniProt (G1TM55) Pfam (PF01092)	Oryctolagus cuniculus (rabbit)
58	FB (HH)	eS7	polymer	194	22168.9	1	UniProt (G1SVB0)	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S7
59	GB (II)	eS8	polymer	206	24003.0	1	UniProt (G1TJW1) Pfam (PF01201)	Oryctolagus cuniculus (rabbit)
60	HB (JJ)	uS4	polymer	185	21649.6	1	UniProt (B7NZS8) Pfam (PF00163) Pfam (PF01479)	Oryctolagus cuniculus (rabbit)
61	IB (KK)	eS10	polymer	96	11529.7	1	UniProt (G1TPV3) Pfam (PF03501)	Oryctolagus cuniculus (rabbit)
62	JB (LL)	uS17	polymer	158	18468.8	1	UniProt (G1TRM4) Pfam (PF16205) Pfam (PF00366)	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S11
63	KB (MM)	eS12	polymer	117	13048.2	1	UniProt (G1SFR8) Pfam (PF01248)	Oryctolagus cuniculus (rabbit)
64	LB (NN)	uS15	polymer	149	17057.1	1	UniProt (G1SP51) Pfam (PF08069) Pfam (PF00312)	Oryctolagus cuniculus (rabbit)
65	MB (OO)	uS11	polymer	136	14544.7	1	UniProt (G1U472) Pfam (PF00411) UniProt (by SIFTS) (G1T1F0)	Oryctolagus cuniculus (rabbit)
66	NB (PP)	uS19	polymer	120	14246.9	1	UniProt (G1U0Q2) Pfam (PF00203)	Oryctolagus cuniculus (rabbit)
67	OB (QQ)	uS9	polymer	142	16032.8	1	UniProt (G1SGX4) Pfam (PF00380)	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S16
68	PB (RR)	eS17	polymer	132	15250.7	1	UniProt (G1TU13) Pfam (PF00833)	Oryctolagus cuniculus (rabbit)
69	QB (SS)	uS13	polymer	144	16898.6	1	UniProt (G1TPG3) Pfam (PF00416)	Oryctolagus cuniculus (rabbit)
70	RB (TT)	eS19	polymer	141	15611.0	1	UniProt (G1TN62) Pfam (PF01090)	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S19
71	SB (UU)	uS10	polymer	100	11395.5	1	UniProt (G1SIZ2) Pfam (PF00338)	Oryctolagus cuniculus (rabbit)
72	TB (VV)	eS21	polymer	83	9124.4	1	UniProt (G1TM82) Pfam (PF01249)	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S21
73	UB (WW)	uS8	polymer	129	14734.4	1	UniProt (G1TG89) Pfam (PF00410)	Oryctolagus cuniculus (rabbit)
74	VB (XX)	uS12	polymer	141	15626.4	1	UniProt (G1SZ47) Pfam (PF00164)	Oryctolagus cuniculus (rabbit)
75	WB (YY)	eS24	polymer	124	14432.1	1	UniProt (G1T3D8) Pfam (PF01282)	Oryctolagus cuniculus (rabbit)
76	XB (ZZ)	eS25	polymer	75	8526.1	1	UniProt (G1TDB3) Pfam (PF03297)	Oryctolagus cuniculus (rabbit)
77	YB (aa)	eS26	polymer	101	11645.8	1	UniProt (G1TFE8) Pfam (PF01283)	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S26
78	ZB (bb)	eS27	polymer	83	9349.0	1	UniProt (G1TZ76) Pfam (PF01667)	Oryctolagus cuniculus (rabbit)
79	AC (cc)	eS28	polymer	62	7007.1	1	UniProt (G1TIB4) Pfam (PF01200)	Oryctolagus cuniculus (rabbit)
80	BC (dd)	uS14	polymer	55	6559.6	1	UniProt (G1U7M4) Pfam (PF00253)	Oryctolagus cuniculus (rabbit)
81	CC (ee)	eS30	polymer	55	6317.5	1	UniProt (G1T8A2) Pfam (PF04758)	Oryctolagus cuniculus (rabbit)
82	DC (ff)	eS31	polymer	68	7986.4	1	UniProt (G1SK22) Pfam (PF00240) Pfam (PF01599)	Oryctolagus cuniculus (rabbit)
83	EC (gg)	RACK1	polymer	313	34669.1	1	UniProt (G1SJB4) Pfam (PF00400)	Oryctolagus cuniculus (rabbit)
84	AD, AE, AF, AG, AH... (5, 7, 9, 8, A...)	MAGNESIUM ION	non-polymer		24.3	294	Chemie (MG)
85	KK, NK, OK, PK, QK... (g, j, m, o, p...)	ZINC ION	non-polymer		65.4	8	Chemie (ZN)
86	SK (v)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	1	Chemie (GDP)

Sequence modifications

G: 1 - 319 (UniProt: G1STW0)

PDB	External Database	Details
Gly 244	Cys 244	conflict

L: 1 - 211 (UniProt: G1TPV0)

PDB	External Database	Details
Ile 46	-	insertion
Ala 47	-	insertion
Pro 48	-	insertion
Arg 49	-	insertion
Pro 50	-	insertion
Ala 51	-	insertion
Ala 52	-	insertion
Gly 53	-	insertion
Pro 54	-	insertion

P: 1 - 213 (UniProt: G1TVT6)

PDB	External Database	Details
Ser 43	Ala 43	conflict

Q: 1 - 188 (UniProt: G1TFE0)

PDB	External Database	Details
Asp 4	Asn 4	conflict
Arg 14	Trp 14	conflict
Met 53	Leu 53	conflict
Arg 58	Trp 58	conflict
Arg 75	Gln 75	conflict
Ala 80	Pro 80	conflict
Val 86	Ile 86	conflict
Arg 104	His 104	conflict
Arg 110	Cys 110	conflict
Val 137	Gly 137	conflict
Gly 157	Arg 157	conflict
Arg 181	Trp 181	conflict

U: 1 - 128 (UniProt: G1TSG1)

PDB	External Database	Details
Leu 18	Val 18	conflict
Gly 32	Arg 32	conflict
Ala 36	Glu 36	conflict
Phe 39	Ser 39	conflict
Gly 54	Arg 54	conflict
Val 60	Ala 60	conflict
Ser 62	Thr 62	conflict
Leu 63	Ile 63	conflict
Arg 97	His 97	conflict
Thr 106	Ser 106	conflict
Glu 126	Asp 126	conflict

W: 1 - 157 (UniProt: G1SE28)

PDB	External Database	Details
Ser 78	Phe 78	conflict

AA: 1 - 295 (UniProt: G1TLT8)

PDB	External Database	Details
Thr 114	Ala 114	conflict

7: 1 - 120 (GenBank: X06789.1)

PDB	External Database	Details
U 2	N 2	conflict
C 36	N 36	conflict
U 102	N 102	conflict
U 112	N 112	conflict
U 114	N 114	conflict
U 119	C 119	conflict
U 120	N 120	conflict

II: 2 - 207 (UniProt: G1TJW1)

PDB	External Database	Details
Arg 47	Gly 47	conflict

TT: 3 - 143 (UniProt: G1TN62)

PDB	External Database	Details
Gly 119	Trp 119	conflict

VV: 1 - 83 (UniProt: G1TM82)

PDB	External Database	Details
Asn 3	Ser 3	conflict
Asp 4	Asn 4	conflict
Gln 33	Pro 33	conflict
Phe 50	Ser 50	conflict
Ala 75	Ser 75	conflict
Asp 76	His 76	conflict
Lys 81	Gln 81	conflict

aa: 2 - 102 (UniProt: G1TFE8)

PDB	External Database	Details
Arg 28	Cys 28	conflict
Ala 56	Val 56	conflict

Sequence viewer

Contents of the asymmetric unit

Polymers	Number of chains	83
Polymers	Total formula weight	3364498.2
Non-Polymers*	Number of molecules	303
Non-Polymers*	Total formula weight	8112.1
All*	Total formula weight	3372610.4

*Water molecules are not included.

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)